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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F12%3A00378773%21RIV13-AV0-61388971
rdf:type
n17:Vysledek skos:Concept
dcterms:description
Like many organisms the fungal pathogen Candida albicans senses changes in the environmental CO2 concentration. This response involves two major proteins: adenylyl cyclase and carbonic anhydrase (CA). Here, we demonstrate that CA expression is tightly controlled by the availability of CO2 and identify the bZIP transcription factor Rca1p as the first CO2 regulator of CA expression in yeast. We show that Rca1p upregulates CA expression during contact with mammalian phagocytes and demonstrate that serine 124 is critical for Rca1p signaling, which occurs independently of adenylyl cyclase Like many organisms the fungal pathogen Candida albicans senses changes in the environmental CO2 concentration. This response involves two major proteins: adenylyl cyclase and carbonic anhydrase (CA). Here, we demonstrate that CA expression is tightly controlled by the availability of CO2 and identify the bZIP transcription factor Rca1p as the first CO2 regulator of CA expression in yeast. We show that Rca1p upregulates CA expression during contact with mammalian phagocytes and demonstrate that serine 124 is critical for Rca1p signaling, which occurs independently of adenylyl cyclase
dcterms:title
The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO2 Sensing Pathway in Yeast The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO2 Sensing Pathway in Yeast
skos:prefLabel
The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO2 Sensing Pathway in Yeast The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO2 Sensing Pathway in Yeast
skos:notation
RIV/61388971:_____/12:00378773!RIV13-AV0-61388971
n17:predkladatel
n20:ico%3A61388971
n3:aktivita
n15:Z n15:P
n3:aktivity
P(LC531), Z(AV0Z50200510)
n3:cisloPeriodika
1
n3:dodaniDat
n5:2013
n3:domaciTvurceVysledku
n12:1218182
n3:druhVysledku
n18:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
125763
n3:idVysledku
RIV/61388971:_____/12:00378773
n3:jazykVysledku
n19:eng
n3:klicovaSlova
CARBONIC-ANHYDRASE CAN2; CANDIDA-ALBICANS; SACCHAROMYCES-CEREVISIAE
n3:klicoveSlovo
n9:CANDIDA-ALBICANS n9:CARBONIC-ANHYDRASE%20CAN2 n9:SACCHAROMYCES-CEREVISIAE
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[CB6EAC0D06CD]
n3:nazevZdroje
P L o S Pathogens
n3:obor
n10:EE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
12
n3:projekt
n7:LC531
n3:rokUplatneniVysledku
n5:2012
n3:svazekPeriodika
8
n3:tvurceVysledku
Kurzai, O. Mühlschlegel, F. A. Palková, Z. Raymond, M. Cottier, F. Lorenz, M. C. Váchová, Libuše Leewattanapasuk, W. Sanglard, D. Bolstad, M. Jiménez-López, M. Pavelka, N.
n3:wos
000300767100031
n3:zamer
n8:AV0Z50200510
s:issn
1553-7366
s:numberOfPages
13
n4:doi
10.1371/journal.ppat.1002485