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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F12%3A00377981%21RIV13-GA0-61388971
rdf:type
skos:Concept n15:Vysledek
dcterms:description
One of the promising approaches in the therapy of ulcerative colitis is administration of butyrate, an energy source for colonocytes, into the lumen of the colon. This study investigates the effect of butyrate producing bakterium Clostridium tyrobutyricum on dextran sodium sulphate (DSS)-induced colitis in mice. Immunocompetent BALB/c and immunodeficient severe combined immunodeficiency (SCID) mice reared in specific-pathogen-free (SPF) conditions were treated intrarectally with C. tyrobutyricum 1 week prior to the induction of DSS colitis and during oral DSS treatment. Administration of DSS without C. tyrobutyricum treatment led to an appearance of clinical symptoms – bleeding, rectal prolapses and colitis-induced increase in the antigen CD11b, a marker of infiltrating inflammatory cells in the lamina propria One of the promising approaches in the therapy of ulcerative colitis is administration of butyrate, an energy source for colonocytes, into the lumen of the colon. This study investigates the effect of butyrate producing bakterium Clostridium tyrobutyricum on dextran sodium sulphate (DSS)-induced colitis in mice. Immunocompetent BALB/c and immunodeficient severe combined immunodeficiency (SCID) mice reared in specific-pathogen-free (SPF) conditions were treated intrarectally with C. tyrobutyricum 1 week prior to the induction of DSS colitis and during oral DSS treatment. Administration of DSS without C. tyrobutyricum treatment led to an appearance of clinical symptoms – bleeding, rectal prolapses and colitis-induced increase in the antigen CD11b, a marker of infiltrating inflammatory cells in the lamina propria
dcterms:title
Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-α and interleukin-18 in BALB/c and severe combined immunodeficiency mice Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-α and interleukin-18 in BALB/c and severe combined immunodeficiency mice
skos:prefLabel
Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-α and interleukin-18 in BALB/c and severe combined immunodeficiency mice Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-α and interleukin-18 in BALB/c and severe combined immunodeficiency mice
skos:notation
RIV/61388971:_____/12:00377981!RIV13-GA0-61388971
n15:predkladatel
n16:ico%3A61388971
n3:aktivita
n19:P n19:Z
n3:aktivity
P(2B06155), P(GA303/08/0367), P(GA303/09/0449), P(GAP304/11/1252), P(ME10017), Z(AV0Z50110509), Z(AV0Z50200510)
n3:cisloPeriodika
2
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n9:2583518 n9:9228810 Du, Zhengyu n9:6536239 n9:2160900 n9:8454884 n9:9530304 n9:1455931 n9:2572214
n3:druhVysledku
n18:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
163050
n3:idVysledku
RIV/61388971:_____/12:00377981
n3:jazykVysledku
n13:eng
n3:klicovaSlova
butyrate; Clostridium tyrobutyricum; confocal fluorimetry
n3:klicoveSlovo
n4:butyrate n4:Clostridium%20tyrobutyricum n4:confocal%20fluorimetry
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[3A83C4BC4060]
n3:nazevZdroje
Clinical and Experimental Immunology
n3:obor
n11:EC
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
13
n3:projekt
n8:GA303%2F08%2F0367 n8:2B06155 n8:GA303%2F09%2F0449 n8:GAP304%2F11%2F1252 n8:ME10017
n3:rokUplatneniVysledku
n12:2012
n3:svazekPeriodika
167
n3:tvurceVysledku
Hrnčíř, Tomáš Kozáková, Hana Hudcovic, Tomáš Šrůtková, Dagmar Wells, J. M. Štěpánková, Renata Kolínská, Jiřina Tlaskalová-Hogenová, Helena Klepetář, Jan Du, Zhengyu Schwarzer, Martin Řezanka, Tomáš Erban, V.
n3:wos
000299037700021
n3:zamer
n10:AV0Z50110509 n10:AV0Z50200510
s:issn
0009-9104
s:numberOfPages
10
n20:doi
10.1111/j.1365-2249.2011.04498.x