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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F12%3A00377498%21RIV13-GA0-61388971
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Silent information regulators are NAD(+)-dependent enzymes that display differential specificity toward acetylated substrates. This report provides first evidence for deacetylation activity of CobB1 in Streptomyces coelicolor. The protein is highly conserved in streptomycetes. The CobB1 protein catalytically removes the acetyl group from acetylated bovine serum albumin. In the absence of NAD(+) or when NAD(+) was substituted with nicotinamide, deacetylation was stopped. We isolated gene encoding AcetylCoA synthetaseA. The recombinant enzyme produces Acetyl-CoA from acetate. The highest acsA-mRNA level was detected in cells from the exponential phase of growth, and then decreased in transition and stationary phases of growth Silent information regulators are NAD(+)-dependent enzymes that display differential specificity toward acetylated substrates. This report provides first evidence for deacetylation activity of CobB1 in Streptomyces coelicolor. The protein is highly conserved in streptomycetes. The CobB1 protein catalytically removes the acetyl group from acetylated bovine serum albumin. In the absence of NAD(+) or when NAD(+) was substituted with nicotinamide, deacetylation was stopped. We isolated gene encoding AcetylCoA synthetaseA. The recombinant enzyme produces Acetyl-CoA from acetate. The highest acsA-mRNA level was detected in cells from the exponential phase of growth, and then decreased in transition and stationary phases of growth
dcterms:title
CobB1 deacetylase activity in Streptomyces coelicolor CobB1 deacetylase activity in Streptomyces coelicolor
skos:prefLabel
CobB1 deacetylase activity in Streptomyces coelicolor CobB1 deacetylase activity in Streptomyces coelicolor
skos:notation
RIV/61388971:_____/12:00377498!RIV13-GA0-61388971
n9:predkladatel
n16:ico%3A61388971
n3:aktivita
n4:Z n4:P
n3:aktivity
P(GA303/09/0475), P(IAA500110805), Z(AV0Z50110509), Z(AV0Z50200510)
n3:cisloPeriodika
2
n3:dodaniDat
n11:2013
n3:domaciTvurceVysledku
n10:7260970 n10:4648609 n10:1359428 n10:3882284 n10:6444962
n3:druhVysledku
n6:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
127582
n3:idVysledku
RIV/61388971:_____/12:00377498
n3:jazykVysledku
n12:eng
n3:klicovaSlova
sirtuin; NAD(+)dependent deacetylation activity CobB1; Streptomyces coeliocolor
n3:klicoveSlovo
n7:NAD%28%2B%29dependent%20deacetylation%20activity%20CobB1 n7:Streptomyces%20coeliocolor n7:sirtuin
n3:kodStatuVydavatele
CA - Kanada
n3:kontrolniKodProRIV
[196718A84612]
n3:nazevZdroje
Biochemistry and Cell Biology
n3:obor
n8:EE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
8
n3:projekt
n15:IAA500110805 n15:GA303%2F09%2F0475
n3:rokUplatneniVysledku
n11:2012
n3:svazekPeriodika
90
n3:tvurceVysledku
Mikulík, Karel Zídková, J. Šetinová, Dita Bezoušková, Silvia Felsberg, Jürgen Zídek, Václav Stodůlková, Eva Kudrnáčová, E.
n3:wos
000302229800007
n3:zamer
n18:AV0Z50110509 n18:AV0Z50200510
s:issn
0829-8211
s:numberOfPages
9
n20:doi
10.1139/O11-086