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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F11%3A00374062%21RIV12-AV0-61388971
rdf:type
n19:Vysledek skos:Concept
dcterms:description
The current molecular, serological and emphasized mass spectral approaches used in fungal diagnostics are evaluated. An overview of low-molecular weight metabolites that have been used in medical mycology during either in vitro or in vivo experiments is presented. Fungal spores are suggested as a viable source of fungal biomarkers, as conidia inhalation is an important entrance gateway to host infection. In addition to MALDI (Matrix Assisted Laser Desorption/Ionization) typing, an alternative diagnostic method based on the knowledge of specific nonribosomal and other fungal metabolite structures is suggested. This approach can be used in fungal mixture analysis and represents a similar benefit to what we have learned from proteomics: going from peptide mapping to peptide sequencing could give better identification rates The current molecular, serological and emphasized mass spectral approaches used in fungal diagnostics are evaluated. An overview of low-molecular weight metabolites that have been used in medical mycology during either in vitro or in vivo experiments is presented. Fungal spores are suggested as a viable source of fungal biomarkers, as conidia inhalation is an important entrance gateway to host infection. In addition to MALDI (Matrix Assisted Laser Desorption/Ionization) typing, an alternative diagnostic method based on the knowledge of specific nonribosomal and other fungal metabolite structures is suggested. This approach can be used in fungal mixture analysis and represents a similar benefit to what we have learned from proteomics: going from peptide mapping to peptide sequencing could give better identification rates
dcterms:title
Fungal Metabolites for Microorganism Classification by Mass Spectrometry Fungal Metabolites for Microorganism Classification by Mass Spectrometry
skos:prefLabel
Fungal Metabolites for Microorganism Classification by Mass Spectrometry Fungal Metabolites for Microorganism Classification by Mass Spectrometry
skos:notation
RIV/61388971:_____/11:00374062!RIV12-AV0-61388971
n19:predkladatel
n21:ico%3A61388971
n4:aktivita
n9:P n9:Z
n4:aktivity
P(LC07017), Z(AV0Z50200510)
n4:dodaniDat
n8:2012
n4:domaciTvurceVysledku
n16:4140702 n16:4316851
n4:druhVysledku
n5:C
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
200561
n4:idVysledku
RIV/61388971:_____/11:00374062
n4:jazykVysledku
n6:eng
n4:klicovaSlova
Microorganism; mass spectrometry; biomarker
n4:klicoveSlovo
n7:mass%20spectrometry n7:Microorganism n7:biomarker
n4:kontrolniKodProRIV
[42BAC4CB530C]
n4:mistoVydani
Washington DC
n4:nazevZdroje
Rapid Characterization of Microorganisms by Mass Spectrometry
n4:obor
n12:EE
n4:pocetDomacichTvurcuVysledku
2
n4:pocetStranKnihy
237
n4:pocetTvurcuVysledku
2
n4:projekt
n22:LC07017
n4:rokUplatneniVysledku
n8:2011
n4:tvurceVysledku
Havlíček, Vladimír Lemr, Karel
n4:zamer
n18:AV0Z50200510
s:numberOfPages
10
n10:doi
10.1021/bk-2011-1065
n17:hasPublisher
American Chemical Society
n13:isbn
978-0-8412-2612-8