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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F11%3A00372518%21RIV12-AV0-61388971
rdf:type
n19:Vysledek skos:Concept
dcterms:description
Heterocytous cyanobacteria from various habitats were screened for toxicity to brine shrimp Artemia salina and the murine lymphoblastic cell line Sp/2 in order to compare these two testing models for evaluation of risk posed by cyanobacteria to human health. Methanol extracts of biomass and cultivation media were tested for toxicity and selected extracts were fractionated to determine the active fraction. We found a significant toxic effect to A. sauna and to Sp/2 cells in 5.2% and 31% of studied extracts, respectively. Only 8.6% of the tested strains were highly toxic to both A. sauna and the Sp/2 cell line, and only two of the tested strains were toxic to A. sauna and not to the murine cell line Heterocytous cyanobacteria from various habitats were screened for toxicity to brine shrimp Artemia salina and the murine lymphoblastic cell line Sp/2 in order to compare these two testing models for evaluation of risk posed by cyanobacteria to human health. Methanol extracts of biomass and cultivation media were tested for toxicity and selected extracts were fractionated to determine the active fraction. We found a significant toxic effect to A. sauna and to Sp/2 cells in 5.2% and 31% of studied extracts, respectively. Only 8.6% of the tested strains were highly toxic to both A. sauna and the Sp/2 cell line, and only two of the tested strains were toxic to A. sauna and not to the murine cell line
dcterms:title
Cyanobacterial cytotoxicity versus toxicity to brine shrimp Artemia salina Cyanobacterial cytotoxicity versus toxicity to brine shrimp Artemia salina
skos:prefLabel
Cyanobacterial cytotoxicity versus toxicity to brine shrimp Artemia salina Cyanobacterial cytotoxicity versus toxicity to brine shrimp Artemia salina
skos:notation
RIV/61388971:_____/11:00372518!RIV12-AV0-61388971
n19:predkladatel
n20:ico%3A61388971
n3:aktivita
n15:Z n15:P
n3:aktivity
P(GAP504/10/1501), Z(AV0Z50200510), Z(AV0Z60170517), Z(AV0Z60660521), Z(MSM6007665801), Z(MSM6007665808)
n3:cisloPeriodika
1
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n8:5093279 n8:8725829
n3:druhVysledku
n5:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
192562
n3:idVysledku
RIV/61388971:_____/11:00372518
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Secondary metabolites; Brine shrimp bioassay; Health risk assessment
n3:klicoveSlovo
n14:Health%20risk%20assessment n14:Brine%20shrimp%20bioassay n14:Secondary%20metabolites
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[B928446423F7]
n3:nazevZdroje
Toxicon
n3:obor
n16:EE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:projekt
n13:GAP504%2F10%2F1501
n3:rokUplatneniVysledku
n11:2011
n3:svazekPeriodika
57
n3:tvurceVysledku
Tomek, P. Hisem, D. Kopecký, Jiří Zapomělová, Eliška Tomšíčková, J. Lukešová, Alena Hrouzek, Pavel Skácelová, K.
n3:wos
000286997300009
n3:zamer
n4:MSM6007665801 n4:MSM6007665808 n4:AV0Z50200510 n4:AV0Z60660521 n4:AV0Z60170517
s:issn
0041-0101
s:numberOfPages
8
n9:doi
10.1016/j.toxicon.2010.10.002