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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F11%3A00366522%21RIV12-AV0-61388971
rdf:type
n12:Vysledek skos:Concept
dcterms:description
This work reveals new structural relationships in the complex process of the interaction between activation receptors of natural killer cells (rat NKR-P1, human CD69) and novel bivalent carbohydrate glycomimetics. The length, glycosylation pattern and linker structure of receptor ligands were examined with respect to their ability to precipitate the receptor protein from solution, which simulates the in vivo process of receptor aggregation during NK cell activation. It was found that di-LacdiNAc triazole compounds show optimal performance, reaching up to 100 percent precipitation of the present protein receptors, and achieving high immunostimulatory activities without any tendency to trigger activation-induced apoptosis. In the synthesis of the compounds tested, two enzymatic approaches were applied This work reveals new structural relationships in the complex process of the interaction between activation receptors of natural killer cells (rat NKR-P1, human CD69) and novel bivalent carbohydrate glycomimetics. The length, glycosylation pattern and linker structure of receptor ligands were examined with respect to their ability to precipitate the receptor protein from solution, which simulates the in vivo process of receptor aggregation during NK cell activation. It was found that di-LacdiNAc triazole compounds show optimal performance, reaching up to 100 percent precipitation of the present protein receptors, and achieving high immunostimulatory activities without any tendency to trigger activation-induced apoptosis. In the synthesis of the compounds tested, two enzymatic approaches were applied
dcterms:title
Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors
skos:prefLabel
Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors
skos:notation
RIV/61388971:_____/11:00366522!RIV12-AV0-61388971
n12:predkladatel
n13:ico%3A61388971
n3:aktivita
n18:S n18:P n18:Z
n3:aktivity
P(GA303/09/0477), P(GD305/09/H008), P(GP203/09/P024), S, Z(AV0Z50200510), Z(MSM0021620808)
n3:cisloPeriodika
12
n3:dodaniDat
n16:2012
n3:domaciTvurceVysledku
n5:1927469 n5:3895831 n5:7203993 n5:2525658 n5:1220489 n5:5894190 n5:6883753 n5:5084954 n5:7072104 n5:7346689 n5:8732124
n3:druhVysledku
n15:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
197799
n3:idVysledku
RIV/61388971:_____/11:00366522
n3:jazykVysledku
n8:eng
n3:klicovaSlova
beta-N-Acetylhexosaminidase; alactosyltransferase; Enzymatic glycosylation
n3:klicoveSlovo
n4:Enzymatic%20glycosylation n4:alactosyltransferase n4:beta-N-Acetylhexosaminidase
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[A8591FAF158C]
n3:nazevZdroje
Carbohydrate Research
n3:obor
n11:CE
n3:pocetDomacichTvurcuVysledku
11
n3:pocetTvurcuVysledku
15
n3:projekt
n10:GA303%2F09%2F0477 n10:GD305%2F09%2FH008 n10:GP203%2F09%2FP024
n3:rokUplatneniVysledku
n16:2011
n3:svazekPeriodika
346
n3:tvurceVysledku
Adámek, David Drozdová, Anna Pelantová, Helena Krupová, Monika Christensen, H. Hensen, B. Elling, L. Křenek, Karel Kuzma, Marek Jensen, H. H. Křen, Vladimír Weignerová, Lenka Bezouška, Karel Bojarová, Pavla Slámová, Kristýna
n3:wos
000292852100029
n3:zamer
n17:MSM0021620808 n17:AV0Z50200510
s:issn
0008-6215
s:numberOfPages
11
n14:doi
10.1016/j.carres.2011.04.043