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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F11%3A00360713%21RIV12-AV0-61388971
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Thanks to the stability, good availability, stereoselectivity and broad substrate specificity, oligosacharide synthesis catalyzed by glycosidases represents an elegant way to komplex carbohydrate structures. Two approaches to glycosidase catalysis are presented: i) the use of structurally modified substrates that carry various functional moieties in the molecule, and ii) the design of mutant glycosidases void of hydrolytic activity. Products of glycosidase catalyzed synthesis are applicable in a range of areas such as immunology, therapy of Alzheimer’s or Parkinson’s diseases and the synthesis of neoglycoproteins Thanks to the stability, good availability, stereoselectivity and broad substrate specificity, oligosacharide synthesis catalyzed by glycosidases represents an elegant way to komplex carbohydrate structures. Two approaches to glycosidase catalysis are presented: i) the use of structurally modified substrates that carry various functional moieties in the molecule, and ii) the design of mutant glycosidases void of hydrolytic activity. Products of glycosidase catalyzed synthesis are applicable in a range of areas such as immunology, therapy of Alzheimer’s or Parkinson’s diseases and the synthesis of neoglycoproteins
dcterms:title
Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short
skos:prefLabel
Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short
skos:notation
RIV/61388971:_____/11:00360713!RIV12-AV0-61388971
n9:predkladatel
n14:ico%3A61388971
n3:aktivita
n11:Z n11:P
n3:aktivity
P(GP203/09/P024), P(LC06010), P(OC09045), Z(AV0Z50200510)
n3:cisloPeriodika
1-2
n3:dodaniDat
n15:2012
n3:domaciTvurceVysledku
n8:3895831 n8:5894190
n3:druhVysledku
n20:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
201388
n3:idVysledku
RIV/61388971:_____/11:00360713
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Carbohydrate; Enzymatic synthesis; Glycosidase
n3:klicoveSlovo
n7:Glycosidase n7:Enzymatic%20synthesis n7:Carbohydrate
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[031266DAC9A6]
n3:nazevZdroje
Chimia
n3:obor
n16:CC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n19:OC09045 n19:GP203%2F09%2FP024 n19:LC06010
n3:rokUplatneniVysledku
n15:2011
n3:svazekPeriodika
65
n3:tvurceVysledku
Křen, Vladimír Bojarová, Pavla
n3:wos
000287981400013
n3:zamer
n12:AV0Z50200510
s:issn
0009-4293
s:numberOfPages
6
n17:doi
10.2533/chimia.2011.65