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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F10%3A00354289%21RIV11-MSM-61388971
rdf:type
n17:Vysledek skos:Concept
dcterms:description
The intraocular lens contains high levels of both cholesterol and sphingolipids, which are believed to be functionally important for normal lens physiology. The aim of this study was to explore the spatial distribution of sphingolipids in the ocular lens using mass spectrometry imaging (MSI). Matrix-assisted laser desorption/ionization (MALDI) imaging with ultra high resolution Fourier transform ion cyklotron resonance mass spectrometry (FT-ICR MS) was used to visualize the lipid spatial distribution. Equatorially-cryosectioned, 12 um thick slices of tissue were thaw-mounted to an indium-tin oxide (ITO) glass slide by soft-landing to an ethanol layer. After the automated MALDI matrix deposition, the entire lens section was examined by MALDI MSI in a 150 um raster. We obtained spatial and concentration-dependent distributions of seven lens sphingomyelins (SM) and two ceramide-1-phosphates (CerP), which are important lipid second messengers The intraocular lens contains high levels of both cholesterol and sphingolipids, which are believed to be functionally important for normal lens physiology. The aim of this study was to explore the spatial distribution of sphingolipids in the ocular lens using mass spectrometry imaging (MSI). Matrix-assisted laser desorption/ionization (MALDI) imaging with ultra high resolution Fourier transform ion cyklotron resonance mass spectrometry (FT-ICR MS) was used to visualize the lipid spatial distribution. Equatorially-cryosectioned, 12 um thick slices of tissue were thaw-mounted to an indium-tin oxide (ITO) glass slide by soft-landing to an ethanol layer. After the automated MALDI matrix deposition, the entire lens section was examined by MALDI MSI in a 150 um raster. We obtained spatial and concentration-dependent distributions of seven lens sphingomyelins (SM) and two ceramide-1-phosphates (CerP), which are important lipid second messengers
dcterms:title
Vizualizing spatial lipid distribution in porcine lens by MALDI imaging high-resolution mass spectrometry Vizualizing spatial lipid distribution in porcine lens by MALDI imaging high-resolution mass spectrometry
skos:prefLabel
Vizualizing spatial lipid distribution in porcine lens by MALDI imaging high-resolution mass spectrometry Vizualizing spatial lipid distribution in porcine lens by MALDI imaging high-resolution mass spectrometry
skos:notation
RIV/61388971:_____/10:00354289!RIV11-MSM-61388971
n3:aktivita
n8:Z n8:P
n3:aktivity
P(LC07017), Z(AV0Z50200510), Z(MSM6198959216)
n3:cisloPeriodika
8
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n6:8710740 n6:1410636 n6:3378241
n3:druhVysledku
n18:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
295855
n3:idVysledku
RIV/61388971:_____/10:00354289
n3:jazykVysledku
n15:eng
n3:klicovaSlova
ocular lens; sphingolipid; matrix-assisted laser desorption/ionization
n3:klicoveSlovo
n13:sphingolipid n13:matrix-assisted%20laser%20desorption%2Fionization n13:ocular%20lens
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[BC179D09593F]
n3:nazevZdroje
Journal of Lipid Research
n3:obor
n12:EE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n7:LC07017
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
51
n3:tvurceVysledku
Novák, Petr Pól, Jaroslav Vidová, V. Holopainen, J. Volný, Michael Wiedmer, S. K.
n3:wos
000279896800025
n3:zamer
n11:MSM6198959216 n11:AV0Z50200510
s:issn
0022-2275
s:numberOfPages
8