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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F09%3A00340980%21RIV10-MSM-61388971
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Antimicrobial drugs that target directly the cell surface structures, resulting in cell permeabilization, were screened by our fluorescence method based on the use of the potentiometric fluorescent probe diS-C3(3). DiS-C3(3) is a substrate for two major S. cerevisiae MDR pumps, Pdr5p and Snq2p. Its use represents an efficient strategy for identifying pump inhibitors with minimal side effects on membrane potential or membrane integrity, and for detecting cells permeabilized by surface active drugs. The screening is performed on cells in well-defined physiological state and does not require any pretreatment or preincubation Antimicrobial drugs that target directly the cell surface structures, resulting in cell permeabilization, were screened by our fluorescence method based on the use of the potentiometric fluorescent probe diS-C3(3). DiS-C3(3) is a substrate for two major S. cerevisiae MDR pumps, Pdr5p and Snq2p. Its use represents an efficient strategy for identifying pump inhibitors with minimal side effects on membrane potential or membrane integrity, and for detecting cells permeabilized by surface active drugs. The screening is performed on cells in well-defined physiological state and does not require any pretreatment or preincubation
dcterms:title
Fast estimation of modes of action of antimicrobials on yeast Saccharomyces cerevisiae - from MDR pump inhibition with a minimal effect on membrane potential up to cell permeabilizatio Fast estimation of modes of action of antimicrobials on yeast Saccharomyces cerevisiae - from MDR pump inhibition with a minimal effect on membrane potential up to cell permeabilizatio
skos:prefLabel
Fast estimation of modes of action of antimicrobials on yeast Saccharomyces cerevisiae - from MDR pump inhibition with a minimal effect on membrane potential up to cell permeabilizatio Fast estimation of modes of action of antimicrobials on yeast Saccharomyces cerevisiae - from MDR pump inhibition with a minimal effect on membrane potential up to cell permeabilizatio
skos:notation
RIV/61388971:_____/09:00340980!RIV10-MSM-61388971
n4:aktivita
n10:Z n10:P
n4:aktivity
P(1M0570), Z(AV0Z50200510)
n4:dodaniDat
n6:2010
n4:domaciTvurceVysledku
n12:8377898 n12:6216277
n4:druhVysledku
n13:O
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
314695
n4:idVysledku
RIV/61388971:_____/09:00340980
n4:jazykVysledku
n14:eng
n4:klicovaSlova
mdr pump
n4:klicoveSlovo
n16:mdr%20pump
n4:kontrolniKodProRIV
[89DF71459FBF]
n4:obor
n8:EE
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
5
n4:projekt
n9:1M0570
n4:rokUplatneniVysledku
n6:2009
n4:tvurceVysledku
Drietomská, A. Gášková, Dana Kodedová, M. Hendrych, T. Sigler, Karel
n4:zamer
n11:AV0Z50200510