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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F09%3A00327139%21RIV10-MSM-61388971
rdf:type
n17:Vysledek skos:Concept
dcterms:description
Human placental b1,4-galactosyltransferase-I (EC 2.4.1.38) transfers the galactosyl moiety from UDP-Gal to various GlcNAc or Glc acceptors in vivo. Here, we describe the construction of its Y284L mutant as a His6propeptidecatb4GalT1 construct, in which the Gal-transferase aktivity was totally abolished in favor of its GalNAc-transferase activity. We used this mutant in the synthesis of three monoand bivalent LacdiNAc glycomimetics with good yields. These compounds proved to be powerful ligands of two activation receptors of natural killer cells, NKR-P1 and CD69.A synthetic bivalent tethered di-LacdiNAc is the best currently known precipitation agent for both of these receptors and has promising potential for the development of immunoactive glycodrugs Human placental b1,4-galactosyltransferase-I (EC 2.4.1.38) transfers the galactosyl moiety from UDP-Gal to various GlcNAc or Glc acceptors in vivo. Here, we describe the construction of its Y284L mutant as a His6propeptidecatb4GalT1 construct, in which the Gal-transferase aktivity was totally abolished in favor of its GalNAc-transferase activity. We used this mutant in the synthesis of three monoand bivalent LacdiNAc glycomimetics with good yields. These compounds proved to be powerful ligands of two activation receptors of natural killer cells, NKR-P1 and CD69.A synthetic bivalent tethered di-LacdiNAc is the best currently known precipitation agent for both of these receptors and has promising potential for the development of immunoactive glycodrugs
dcterms:title
Synthesis of LacdiNAc-terminated glycoconjugates by mutant galactosyltransferase – A way to new glycodrugs and materials Synthesis of LacdiNAc-terminated glycoconjugates by mutant galactosyltransferase – A way to new glycodrugs and materials
skos:prefLabel
Synthesis of LacdiNAc-terminated glycoconjugates by mutant galactosyltransferase – A way to new glycodrugs and materials Synthesis of LacdiNAc-terminated glycoconjugates by mutant galactosyltransferase – A way to new glycodrugs and materials
skos:notation
RIV/61388971:_____/09:00327139!RIV10-MSM-61388971
n3:aktivita
n11:P n11:Z
n3:aktivity
P(GA204/06/0771), P(GP203/09/P024), P(LC06010), P(OC 136), Z(AV0Z50200510), Z(MSM0021620808)
n3:cisloPeriodika
5
n3:dodaniDat
n5:2010
n3:domaciTvurceVysledku
n4:7203993 n4:8732124 n4:3895831 n4:5894190 n4:7346689
n3:druhVysledku
n12:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
345110
n3:idVysledku
RIV/61388971:_____/09:00327139
n3:jazykVysledku
n9:eng
n3:klicovaSlova
enzymatic synthesis; glycomimetics; glycosyltransferase
n3:klicoveSlovo
n7:enzymatic%20synthesis n7:glycosyltransferase n7:glycomimetics
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[5B681064A7F0]
n3:nazevZdroje
Glycobiology
n3:obor
n8:CE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
8
n3:projekt
n16:OC%20136 n16:GP203%2F09%2FP024 n16:LC06010 n16:GA204%2F06%2F0771
n3:rokUplatneniVysledku
n5:2009
n3:svazekPeriodika
19
n3:tvurceVysledku
Adamiak, K. Křen, Vladimír Bezouška, Karel Bojarová, Pavla Pelantová, Helena Elling, L. Křenek, Karel Wetjen, K.
n3:wos
000265096000007
n3:zamer
n14:MSM0021620808 n14:AV0Z50200510
s:issn
0959-6658
s:numberOfPages
9