This HTML5 document contains 52 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n13http://linked.opendata.cz/resource/domain/vavai/projekt/
n11http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n18http://linked.opendata.cz/ontology/domain/vavai/
n4http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n16http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F61388971%3A_____%2F06%3A00043280%21RIV07-GA0-61388971/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n15http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n6http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n14http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F06%3A00043280%21RIV07-GA0-61388971
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Byla připravena řada selektivně alkylovaných derivátů silybinu a 2,3-dehydrosilybinu určených pro strukturně-aktivitní studie jejich efektu na inhibici effluxní funkce P-glykoproteinu. Připravené deriváty silybinu/2,3-dehydrosilybinu byly testovány rovněž na cytotoxicitu v panelu buněk citlivých a rezistentních k léčivu. Identifikovali jsme efektivní a relativně netoxické inhibitory P-gp odvozené od 2,3-dehydrosilybinu. Řada z nich vykazovala lepší inhibiční aktivitu než standardní P-gp inhibitor cyklosporin A. V rámci této studie byly také stanoveny strukturní požadavky pro zlepšení inhibiční aktivity a snížení toxicity 2,3-dehydrosilybinu Large series of O-alkyl derivatives of silybin and 2,3-dehydrosilybin was prepared. All prepared silybin/2,3-dehydrosilybin derivatives were tested for cytotoxicity on a panel of drugs sensitive against multidrug resistant cell lines and the ability to inhibit P-glycoprotein mediated efflux activity. We have identified effective and relatively non-cytotoxic inhibitors of P-gp derived from 2,3-dehydrosilybin. Some of them were more effective inhibitors than a standard P-gp efflux inhibitor cyclosporin A. In the frame of this study were established structural requirements for improving inhibitory activity and reducing toxicity of 2,3-dehydrosilybin as well Large series of O-alkyl derivatives of silybin and 2,3-dehydrosilybin was prepared. All prepared silybin/2,3-dehydrosilybin derivatives were tested for cytotoxicity on a panel of drugs sensitive against multidrug resistant cell lines and the ability to inhibit P-glycoprotein mediated efflux activity. We have identified effective and relatively non-cytotoxic inhibitors of P-gp derived from 2,3-dehydrosilybin. Some of them were more effective inhibitors than a standard P-gp efflux inhibitor cyclosporin A. In the frame of this study were established structural requirements for improving inhibitory activity and reducing toxicity of 2,3-dehydrosilybin as well
dcterms:title
Nové deriváty silybinu a 2,3-dehydrosilybinu - jejich cytotoxicita a P-glykoprotein modulační aktivita New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity
skos:prefLabel
New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity Nové deriváty silybinu a 2,3-dehydrosilybinu - jejich cytotoxicita a P-glykoprotein modulační aktivita
skos:notation
RIV/61388971:_____/06:00043280!RIV07-GA0-61388971
n3:strany
3793;3810
n3:aktivita
n5:P n5:Z
n3:aktivity
P(GA303/02/1097), Z(AV0Z50200510), Z(MSM6198959216)
n3:cisloPeriodika
-
n3:dodaniDat
n14:2007
n3:domaciTvurceVysledku
n11:5894190 n11:1569015 n11:5251648
n3:druhVysledku
n6:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
488494
n3:idVysledku
RIV/61388971:_____/06:00043280
n3:jazykVysledku
n17:eng
n3:klicovaSlova
silymarin; silybin; dehydrosilybin
n3:klicoveSlovo
n15:silybin n15:silymarin n15:dehydrosilybin
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[F16AE4BB8A4F]
n3:nazevZdroje
Bioorganic Medical Chemistry
n3:obor
n7:EE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
8
n3:projekt
n13:GA303%2F02%2F1097
n3:rokUplatneniVysledku
n14:2006
n3:svazekPeriodika
14
n3:tvurceVysledku
Gažák, Radek Walterová, Daniela Džubák, P. Sedmera, Petr Hajdúch, M. Psotová, J. Křen, Vladimír Svobodová, A.
n3:zamer
n4:MSM6198959216 n4:AV0Z50200510
s:issn
0968-0896
s:numberOfPages
8