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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F06%3A00043244%21RIV07-GA0-61388971
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Kmen Escherichia coli A0 34/86 (O83:K24:H31) je úspěšně používán pro preventivní kolonizaci novorozenců. V této práci ukazujeme, že jeho bezpečnost lze ještě vylepšit odstraněním genu pro hemolyzín, což neovlivní kolonizační schopnosti kmene v prasečím experimentálním modelu Escherichia coli A0 34/86 (O83:K24:H31) has been successfully used for prophylactic and therapeutic intestinal colonization of premature and newborn infants, with the aim of preventing nosocomial infections. Although E. coli A0 34/86 was described as a nonpathogenic commensal, partial sequencing revealed that its genome harbours gene clusters highly homologous to virulence determinants of different types of E. coli, including closely linked genes of the a-haemolysin operon (hlyCABD) and for the cytotoxic necrotizing factor (cnf1). A haemolysin-deficient mutant (hlyA) of E. coli A0 34/86 was generated and its colonization capacity was determined. The results show that a single dose of the A0 34/86 wild-type or hlyA strains resulted in efficient intestinal colonization of newborn conventional piglets, and that this was still considerable after several weeks Escherichia coli A0 34/86 (O83:K24:H31) has been successfully used for prophylactic and therapeutic intestinal colonization of premature and newborn infants, with the aim of preventing nosocomial infections. Although E. coli A0 34/86 was described as a nonpathogenic commensal, partial sequencing revealed that its genome harbours gene clusters highly homologous to virulence determinants of different types of E. coli, including closely linked genes of the a-haemolysin operon (hlyCABD) and for the cytotoxic necrotizing factor (cnf1). A haemolysin-deficient mutant (hlyA) of E. coli A0 34/86 was generated and its colonization capacity was determined. The results show that a single dose of the A0 34/86 wild-type or hlyA strains resulted in efficient intestinal colonization of newborn conventional piglets, and that this was still considerable after several weeks
dcterms:title
Vyřazení HlyA vede k bezpečnější variantě kmene Escherichia coli A0 34/86 s nezměněnými kolonizačními schopnostmi HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets
skos:prefLabel
HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets Vyřazení HlyA vede k bezpečnější variantě kmene Escherichia coli A0 34/86 s nezměněnými kolonizačními schopnostmi HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets
skos:notation
RIV/61388971:_____/06:00043244!RIV07-GA0-61388971
n4:strany
257;266
n4:aktivita
n14:Z n14:P
n4:aktivity
P(GA523/03/0186), Z(AV0Z50200510)
n4:cisloPeriodika
-
n4:dodaniDat
n13:2007
n4:domaciTvurceVysledku
n12:1076329 Sheshko, Valeria n12:4648609 n12:5377846
n4:druhVysledku
n18:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
477891
n4:idVysledku
RIV/61388971:_____/06:00043244
n4:jazykVysledku
n6:eng
n4:klicovaSlova
escherichia coli; haemolysin; colonization
n4:klicoveSlovo
n11:colonization n11:escherichia%20coli n11:haemolysin
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[74EA50282A6F]
n4:nazevZdroje
FEMS Immunology and Medical Microbiology
n4:obor
n8:EE
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
10
n4:projekt
n16:GA523%2F03%2F0186
n4:rokUplatneniVysledku
n13:2006
n4:svazekPeriodika
48
n4:tvurceVysledku
Šebo, Peter Hejnová, Jana Felsberg, Jürgen Faldyna, M. Sheshko, Valeria Řeháková, Z. Alexa, P. Bomba, A. Šinkora, J. Němcová, R.
n4:zamer
n15:AV0Z50200510
s:issn
0928-8244
s:numberOfPages
12