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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F14%3A00437907%21RIV15-GA0-61388963
rdf:type
skos:Concept n17:Vysledek
dcterms:description
We identified breast cancer-associated protein (BCA3) as a novel binding partner of Mason-Pfizer monkey virus (MPMV) protease (PR). The interaction was confirmed by co-immunoprecipitation and immunocolocalization of MPMV PR and BCA3. Full-length but not C-terminally truncated BOA3 was incorporated into MPMV virions. We ruled out the potential role of the G-patch domain, a glycine-rich domain located at the C terminus of MPMV PR, in BCA3 interaction and virion incorporation. Expression of BCA3 did not affect MPMV particle release and proteolytic processing; however, it slightly increased MPMV infectivity. We identified breast cancer-associated protein (BCA3) as a novel binding partner of Mason-Pfizer monkey virus (MPMV) protease (PR). The interaction was confirmed by co-immunoprecipitation and immunocolocalization of MPMV PR and BCA3. Full-length but not C-terminally truncated BOA3 was incorporated into MPMV virions. We ruled out the potential role of the G-patch domain, a glycine-rich domain located at the C terminus of MPMV PR, in BCA3 interaction and virion incorporation. Expression of BCA3 did not affect MPMV particle release and proteolytic processing; however, it slightly increased MPMV infectivity.
dcterms:title
Breast cancer-associated protein - a novel binding partner of Mason-Pfizer monkey virus protease Breast cancer-associated protein - a novel binding partner of Mason-Pfizer monkey virus protease
skos:prefLabel
Breast cancer-associated protein - a novel binding partner of Mason-Pfizer monkey virus protease Breast cancer-associated protein - a novel binding partner of Mason-Pfizer monkey virus protease
skos:notation
RIV/61388963:_____/14:00437907!RIV15-GA0-61388963
n3:aktivita
n18:P n18:I
n3:aktivity
I, P(GA204/09/1388)
n3:cisloPeriodika
6
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n4:8747784 n4:7526105 n4:6705294 n4:2264102 n4:9597778 n4:8571635 n4:4180178
n3:druhVysledku
n14:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
5791
n3:idVysledku
RIV/61388963:_____/14:00437907
n3:jazykVysledku
n15:eng
n3:klicovaSlova
gene; AKIP1; expression
n3:klicoveSlovo
n8:AKIP1 n8:expression n8:gene
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[99190F92175E]
n3:nazevZdroje
Journal of General Virology
n3:obor
n16:EE
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
8
n3:projekt
n12:GA204%2F09%2F1388
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
95
n3:tvurceVysledku
Strohalmová, Karolína Ruml, T. Keprová, Alena Hadravová, Romana Rumlová, Michaela Doležal, Michal Křížová, Ivana Pichová, Iva
n3:wos
000338176700019
s:issn
0022-1317
s:numberOfPages
7
n5:doi
10.1099/vir.0.064345-0