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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F14%3A00435583%21RIV15-GA0-61388963
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://www.mdpi.com/1424-8247/7/3/251
dcterms:description
Defensins are the most widespread antimicrobial peptides characterised in insects. These cyclic peptides, 4-6 kDa in size, are folded into alpha-helical/beta-sheet mixed structures and have a common conserved motif of three intramolecular disulfide bridges with a Cys1-Cys4, Cys2-Cys5 and Cys3-Cys6 connectivity. They have the ability to kill especially Gram-positive bacteria and some fungi, but Gram-negative bacteria are more resistant against them. Among them are the medicinally important compounds lucifensin and lucifensin II, which have recently been identified in the medicinal larvae of the blowflies Lucilia sericata and Lucilia cuprina, respectively. These defensins contribute to wound healing during a procedure known as maggot debridement therapy (MDT) which is routinely used at hospitals worldwide. Here we discuss the decades-long story of the effort to isolate and characterise these two defensins from the bodies of medicinal larvae or from their secretions/excretions. Furthermore, our previous studies showed that the free-range larvae of L. sericata acutely eliminated most of the Gram-positive strains of bacteria and some Gram-negative strains in patients with infected diabetic foot ulcers, but MDT was ineffective during the healing of wounds infected with Pseudomonas sp. and Acinetobacter sp. The bactericidal role of lucifensins secreted into the infected wound by larvae during MDT and its ability to enhance host immunity by functioning as immunomodulator is also discussed. Defensins are the most widespread antimicrobial peptides characterised in insects. These cyclic peptides, 4-6 kDa in size, are folded into alpha-helical/beta-sheet mixed structures and have a common conserved motif of three intramolecular disulfide bridges with a Cys1-Cys4, Cys2-Cys5 and Cys3-Cys6 connectivity. They have the ability to kill especially Gram-positive bacteria and some fungi, but Gram-negative bacteria are more resistant against them. Among them are the medicinally important compounds lucifensin and lucifensin II, which have recently been identified in the medicinal larvae of the blowflies Lucilia sericata and Lucilia cuprina, respectively. These defensins contribute to wound healing during a procedure known as maggot debridement therapy (MDT) which is routinely used at hospitals worldwide. Here we discuss the decades-long story of the effort to isolate and characterise these two defensins from the bodies of medicinal larvae or from their secretions/excretions. Furthermore, our previous studies showed that the free-range larvae of L. sericata acutely eliminated most of the Gram-positive strains of bacteria and some Gram-negative strains in patients with infected diabetic foot ulcers, but MDT was ineffective during the healing of wounds infected with Pseudomonas sp. and Acinetobacter sp. The bactericidal role of lucifensins secreted into the infected wound by larvae during MDT and its ability to enhance host immunity by functioning as immunomodulator is also discussed.
dcterms:title
Lucifensins, the Insect Defensins of Biomedical Importance: The Story behind Maggot Therapy Lucifensins, the Insect Defensins of Biomedical Importance: The Story behind Maggot Therapy
skos:prefLabel
Lucifensins, the Insect Defensins of Biomedical Importance: The Story behind Maggot Therapy Lucifensins, the Insect Defensins of Biomedical Importance: The Story behind Maggot Therapy
skos:notation
RIV/61388963:_____/14:00435583!RIV15-GA0-61388963
n3:aktivita
n6:P n6:I
n3:aktivity
I, P(GA203/08/0536)
n3:cisloPeriodika
3
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n7:9667598
n3:druhVysledku
n10:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
26734
n3:idVysledku
RIV/61388963:_____/14:00435583
n3:jazykVysledku
n19:eng
n3:klicovaSlova
antimicrobial peptide; insect defensin; lucifensin; maggot therapy; Lucilia sericata; Lucilia cuprina; peptide isolation; peptide identification
n3:klicoveSlovo
n5:Lucilia%20cuprina n5:peptide%20identification n5:maggot%20therapy n5:peptide%20isolation n5:Lucilia%20sericata n5:insect%20defensin n5:lucifensin n5:antimicrobial%20peptide
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[46AA4F978318]
n3:nazevZdroje
Pharmaceuticals
n3:obor
n11:CC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:projekt
n15:GA203%2F08%2F0536
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
7
n3:tvurceVysledku
Čeřovský, Václav Bém, R.
s:issn
1424-8247
s:numberOfPages
14
n12:doi
10.3390/ph7030251