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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F14%3A00430390%21RIV15-GA0-61388963
rdf:type
skos:Concept n11:Vysledek
dcterms:description
The synthesis of a novel library of purine derivatives bearing various bicyclic and polycylic substituents at the N-9 position is described. The series includes norbornanes, bicyclo[2.2.2] octanes, and bicyclo[3.2.1] octanes attached at the bridgehead position as well as bicyclo[3.1.1] heptanes, tetrahydro-1-naphthalenes, and adamantanes bonded either directly or via a linear chain to the 6-chloropurine nucleobase. A number of prepared derivatives exerted significant activity against the enterovirus. Despite attempts to correlate the activity against picornaviruses with their phosphatidylinositol 4-kinase KIII beta inhibitory activity, it is clear that the inhibition of this host factor cannot explain the observed antiviral potency. The synthesis of a novel library of purine derivatives bearing various bicyclic and polycylic substituents at the N-9 position is described. The series includes norbornanes, bicyclo[2.2.2] octanes, and bicyclo[3.2.1] octanes attached at the bridgehead position as well as bicyclo[3.1.1] heptanes, tetrahydro-1-naphthalenes, and adamantanes bonded either directly or via a linear chain to the 6-chloropurine nucleobase. A number of prepared derivatives exerted significant activity against the enterovirus. Despite attempts to correlate the activity against picornaviruses with their phosphatidylinositol 4-kinase KIII beta inhibitory activity, it is clear that the inhibition of this host factor cannot explain the observed antiviral potency.
dcterms:title
Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position
skos:prefLabel
Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position
skos:notation
RIV/61388963:_____/14:00430390!RIV15-GA0-61388963
n4:aktivita
n16:I n16:P
n4:aktivity
I, P(GAP303/11/1297)
n4:cisloPeriodika
7
n4:dodaniDat
n13:2015
n4:domaciTvurceVysledku
n7:2131447 n7:7359608 n7:1570889 n7:4843878 n7:6298036 n7:8609233 n7:4679733 n7:5941814 n7:5104998
n4:druhVysledku
n18:J
n4:duvernostUdaju
n6:S
n4:entitaPredkladatele
n5:predkladatel
n4:idSjednocenehoVysledku
49044
n4:idVysledku
RIV/61388963:_____/14:00430390
n4:jazykVysledku
n15:eng
n4:klicovaSlova
antiviral; coxsackievirus B3; enteroviruses; phosphatidylinositol 4-kinase (PI4K); purines
n4:klicoveSlovo
n10:enteroviruses n10:antiviral n10:coxsackievirus%20B3 n10:purines n10:phosphatidylinositol%204-kinase%20%28PI4K%29
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[5BA0ABF70612]
n4:nazevZdroje
Archiv der Pharmazie
n4:obor
n8:CC
n4:pocetDomacichTvurcuVysledku
9
n4:pocetTvurcuVysledku
12
n4:projekt
n14:GAP303%2F11%2F1297
n4:rokUplatneniVysledku
n13:2014
n4:svazekPeriodika
347
n4:tvurceVysledku
Dejmek, Milan Mertlíková-Kaiserová, Helena Leyssen, P. Procházková, Eliška Nencka, Radim Neyts, J. Plačková, Pavla Šála, Michal Hřebabecký, Hubert Borreda, L. M. Dračínský, Martin Jansa, Petr
n4:wos
000338940600003
s:issn
0365-6233
s:numberOfPages
8
n12:doi
10.1002/ardp.201300431