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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F13%3A00424054%21RIV14-AV0-61388963
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Enantiomerically pure product synthesis plays a key role in production of pharmaceuticals. The application of biocatalytic approaches represents a convenient and sustainable way for this purpose. The enormous potential of enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivity is on increasing awareness. In particular, lipases show a high versatility to recognize non-natural substrates being successfully applied in regio- and stereoselective biotransformations. The immobilization technology on lipases is not only a requisite for the industrial implementation but it has been a great methodology to alter their catalytic properties to obtain highly enantio- and regiose-lective biocatalysts in the enantioselective synthesis of chiral drugs or drug intermediates. This review focuses on showing some of the latest advances on the use of immobilized lipases on pharmaceutical biotransformations. Enantiomerically pure product synthesis plays a key role in production of pharmaceuticals. The application of biocatalytic approaches represents a convenient and sustainable way for this purpose. The enormous potential of enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivity is on increasing awareness. In particular, lipases show a high versatility to recognize non-natural substrates being successfully applied in regio- and stereoselective biotransformations. The immobilization technology on lipases is not only a requisite for the industrial implementation but it has been a great methodology to alter their catalytic properties to obtain highly enantio- and regiose-lective biocatalysts in the enantioselective synthesis of chiral drugs or drug intermediates. This review focuses on showing some of the latest advances on the use of immobilized lipases on pharmaceutical biotransformations.
dcterms:title
Synthesis of enantiopure drugs and drug intermediates by immobilized lipase-catalysis Synthesis of enantiopure drugs and drug intermediates by immobilized lipase-catalysis
skos:prefLabel
Synthesis of enantiopure drugs and drug intermediates by immobilized lipase-catalysis Synthesis of enantiopure drugs and drug intermediates by immobilized lipase-catalysis
skos:notation
RIV/61388963:_____/13:00424054!RIV14-AV0-61388963
n16:predkladatel
n17:ico%3A61388963
n4:aktivita
n11:I
n4:aktivity
I
n4:cisloPeriodika
2
n4:dodaniDat
n7:2014
n4:domaciTvurceVysledku
n6:7985568
n4:druhVysledku
n13:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
109529
n4:idVysledku
RIV/61388963:_____/13:00424054
n4:jazykVysledku
n18:eng
n4:klicovaSlova
lipases; kinetic resolution; asymmetric transformation; chemical modification; immobilization; pharmaceuticals; carbohydrates
n4:klicoveSlovo
n5:immobilization n5:pharmaceuticals n5:asymmetric%20transformation n5:chemical%20modification n5:kinetic%20resolution n5:carbohydrates n5:lipases
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[DE1BF8BFA2AA]
n4:nazevZdroje
Current Bioactive Compounds
n4:obor
n15:CC
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
4
n4:rokUplatneniVysledku
n7:2013
n4:svazekPeriodika
9
n4:tvurceVysledku
Palomo, J. M. Gutarra, M. Filice, M. Brabcová, Jana
s:issn
1573-4072
s:numberOfPages
24
n14:doi
10.2174/22115528112019990009