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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F13%3A00396257%21RIV14-GA0-61388963
rdf:type
skos:Concept n9:Vysledek
dcterms:description
Two series of new 4-aminopyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 5 or 6 have been prepared by Suzuki or Stille cross-coupling reactions employing X-Phos ligand with (het)arylboronic acids or stannanes. A series of 4-substituted nucleosides has been also prepared by Pd-catalyzed cross-couplings or nucleophilic substitution. Some of these compounds displayed moderate antiviral activities against HCV and dengue viruses. Two series of new 4-aminopyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 5 or 6 have been prepared by Suzuki or Stille cross-coupling reactions employing X-Phos ligand with (het)arylboronic acids or stannanes. A series of 4-substituted nucleosides has been also prepared by Pd-catalyzed cross-couplings or nucleophilic substitution. Some of these compounds displayed moderate antiviral activities against HCV and dengue viruses.
dcterms:title
Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5-and 6-substituted 4-amino- or 4-alkylpyrimido [4,5-b]indole ribonucleosides Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5-and 6-substituted 4-amino- or 4-alkylpyrimido [4,5-b]indole ribonucleosides
skos:prefLabel
Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5-and 6-substituted 4-amino- or 4-alkylpyrimido [4,5-b]indole ribonucleosides Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5-and 6-substituted 4-amino- or 4-alkylpyrimido [4,5-b]indole ribonucleosides
skos:notation
RIV/61388963:_____/13:00396257!RIV14-GA0-61388963
n9:predkladatel
n10:ico%3A61388963
n3:aktivita
n12:P n12:I
n3:aktivity
I, P(GAP207/11/0344)
n3:cisloPeriodika
17
n3:dodaniDat
n17:2014
n3:domaciTvurceVysledku
n13:7596782 n13:3603652 n13:6659160 n13:3380351 n13:7485158
n3:druhVysledku
n8:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
109460
n3:idVysledku
RIV/61388963:_____/13:00396257
n3:jazykVysledku
n7:eng
n3:klicovaSlova
nucleosides; pyrimido[4,5-b]indoles; Suzuki and Stille cross-coupling; anti-dengue virus activity
n3:klicoveSlovo
n4:anti-dengue%20virus%20activity n4:Suzuki%20and%20Stille%20cross-coupling n4:pyrimido%5B4 n4:5-b%5Dindoles n4:nucleosides
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[7119EA72AA49]
n3:nazevZdroje
Bioorganic & Medicinal Chemistry
n3:obor
n14:CC
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
7
n3:projekt
n19:GAP207%2F11%2F0344
n3:rokUplatneniVysledku
n17:2013
n3:svazekPeriodika
21
n3:tvurceVysledku
Pohl, Radek Bahador, G. Tichý, Michal Hocek, Michal Weber, Jan Lee, Y. J. Tloušťová, Eva
n3:wos
000323294600054
s:issn
0968-0896
s:numberOfPages
11
n11:doi
10.1016/j.bmc.2013.06.011