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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F13%3A00394921%21RIV14-MSM-61388963
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1155/2013/650610
dcterms:description
Oligonucleotide conjugates carrying a single functionalized tetrathiafulvalene (TTF) unit linked through a threoninol molecule to the 3' or 5' ends were synthesized together with their complementary oligonucleotides carrying a TTF, pyrene, or pentafluorophenyl group. TTF-oligonucleotide conjugates formed duplexes with higher thermal stability than the corresponding unmodified oligonucleotides and pyrene- and pentafluorophenyl-modified oligonucleotides. TTF-modified oligonucleotides are able to bind to citrate-stabilized gold nanoparticles (AuNPs) and produce stable gold AuNPs functionalized with oligonucleotides. Finally, TTF-oligoribonucleotides have been synthesized to produce siRNA duplexes carrying TTF units. The presence of the TTF molecule is compatible with the RNA interference mechanism for gene inhibition. Oligonucleotide conjugates carrying a single functionalized tetrathiafulvalene (TTF) unit linked through a threoninol molecule to the 3' or 5' ends were synthesized together with their complementary oligonucleotides carrying a TTF, pyrene, or pentafluorophenyl group. TTF-oligonucleotide conjugates formed duplexes with higher thermal stability than the corresponding unmodified oligonucleotides and pyrene- and pentafluorophenyl-modified oligonucleotides. TTF-modified oligonucleotides are able to bind to citrate-stabilized gold nanoparticles (AuNPs) and produce stable gold AuNPs functionalized with oligonucleotides. Finally, TTF-oligoribonucleotides have been synthesized to produce siRNA duplexes carrying TTF units. The presence of the TTF molecule is compatible with the RNA interference mechanism for gene inhibition.
dcterms:title
Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions
skos:prefLabel
Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions
skos:notation
RIV/61388963:_____/13:00394921!RIV14-MSM-61388963
n12:predkladatel
n13:ico%3A61388963
n4:aktivita
n8:P n8:I
n4:aktivity
I, P(7E09054), P(GAP207/10/2214)
n4:cisloPeriodika
June
n4:dodaniDat
n14:2014
n4:domaciTvurceVysledku
n5:8624526 n5:7783620 n5:8935971 n5:4128575
n4:druhVysledku
n9:J
n4:duvernostUdaju
n20:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
63532
n4:idVysledku
RIV/61388963:_____/13:00394921
n4:jazykVysledku
n15:eng
n4:klicovaSlova
DNA; derivates; tetrathiafulvalene; TTF-oligonucleotide conjugates
n4:klicoveSlovo
n10:TTF-oligonucleotide%20conjugates n10:tetrathiafulvalene n10:DNA n10:derivates
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[3A17226D3459]
n4:nazevZdroje
Journal of Chemistry
n4:obor
n19:CC
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
8
n4:projekt
n7:7E09054 n7:GAP207%2F10%2F2214
n4:rokUplatneniVysledku
n14:2013
n4:svazekPeriodika
2013
n4:tvurceVysledku
Janoušek, Jiří Stará, Irena G. Eritja, R. Grijalvo, S. Pérez-Rentero, S. Starý, Ivo Bělohradský, Martin Somoza, A.
n4:wos
000322492900001
s:issn
2090-9063
s:numberOfPages
11
n11:doi
10.1155/2013/650610