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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F12%3A00384913%21RIV13-AV0-61388963
rdf:type
skos:Concept n11:Vysledek
dcterms:description
A new benzyldihydroisoquinoline alkaloid (1) was isolated from the tubers of Corydalis cava and named corylucinine. Additionally, 8-trichloromethyl-7,8-dihydropalmatine (2), an isolation artifact of tetrahydropalmatine, was obtained. The structures were established by spectroscopic (including 2D NMR and optical rotation) and HR-ESI-MS methods. Both compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBtiChE) inhibitory activity. In comparison with the used standards, both compounds showed only moderate inhibitory activity against HuAChE (IC50, (HuAChE) = 127.6 +/- 5.2 mu M for 1, and IC50, (HuAchE) = 82.9 +/- 3.9 mu M for 2) and none against HuBuChE. A new benzyldihydroisoquinoline alkaloid (1) was isolated from the tubers of Corydalis cava and named corylucinine. Additionally, 8-trichloromethyl-7,8-dihydropalmatine (2), an isolation artifact of tetrahydropalmatine, was obtained. The structures were established by spectroscopic (including 2D NMR and optical rotation) and HR-ESI-MS methods. Both compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBtiChE) inhibitory activity. In comparison with the used standards, both compounds showed only moderate inhibitory activity against HuAChE (IC50, (HuAChE) = 127.6 +/- 5.2 mu M for 1, and IC50, (HuAchE) = 82.9 +/- 3.9 mu M for 2) and none against HuBuChE.
dcterms:title
Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity
skos:prefLabel
Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity
skos:notation
RIV/61388963:_____/12:00384913!RIV13-AV0-61388963
n11:predkladatel
n13:ico%3A61388963
n3:aktivita
n7:Z n7:S n7:I
n3:aktivity
I, S, Z(AV0Z40550506)
n3:cisloPeriodika
7
n3:dodaniDat
n15:2013
n3:domaciTvurceVysledku
n12:5268893
n3:druhVysledku
n17:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
128888
n3:idVysledku
RIV/61388963:_____/12:00384913
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Corydalis cava; corylucinine; 8-trichloromethyl-7,8-dihydropalmatine; acetylcholinesterase; butyrylcholinesterase; Alzheimer's disease
n3:klicoveSlovo
n8:Corydalis%20cava n8:butyrylcholinesterase n8:corylucinine n8:acetylcholinesterase n8:Alzheimer%27s%20disease n8:8-dihydropalmatine n8:8-trichloromethyl-7
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[5244A7A0028B]
n3:nazevZdroje
Natural Product Communications
n3:obor
n18:CC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n15:2012
n3:svazekPeriodika
7
n3:tvurceVysledku
Kuneš, J. Opletal, L. Novák, Z. Macáková, K. Jiroš, Pavel Cahlíková, L. Chlebek, J.
n3:wos
000306764200012
n3:zamer
n14:AV0Z40550506
s:issn
1934-578X
s:numberOfPages
2