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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F12%3A00379073%21RIV13-AV0-61388963
rdf:type
skos:Concept n12:Vysledek
dcterms:description
The genes APR1 and CPY1 of the pathogenic yeast Candida albicans encode vacuolar aspartic protease and serine carboxypeptidase, respectively. Transcription of both APR1 and CPY1 was upregulated in mid-exponential phase, together with increasing size of the vacuoles, when C. albicans was cultivated in a rich medium at 30 °C. However, simultaneous up-regulation of protein synthesis occurred only for Cpy1p. Analysis of APR1 and CPY1 expression under nitrogen limited conditions revealed, that the genes were regulated on both the transcriptional and translational level and detectable amounts of Apr1p were synthesized only when C. albicans was grown in nitrogen limited media. The genes APR1 and CPY1 of the pathogenic yeast Candida albicans encode vacuolar aspartic protease and serine carboxypeptidase, respectively. Transcription of both APR1 and CPY1 was upregulated in mid-exponential phase, together with increasing size of the vacuoles, when C. albicans was cultivated in a rich medium at 30 °C. However, simultaneous up-regulation of protein synthesis occurred only for Cpy1p. Analysis of APR1 and CPY1 expression under nitrogen limited conditions revealed, that the genes were regulated on both the transcriptional and translational level and detectable amounts of Apr1p were synthesized only when C. albicans was grown in nitrogen limited media.
dcterms:title
Nitrogen source and growth stage of Candida albicans influence expression level of vacuolar aspartic protease Apr1p and carboxypeptidase Cpy1p Nitrogen source and growth stage of Candida albicans influence expression level of vacuolar aspartic protease Apr1p and carboxypeptidase Cpy1p
skos:prefLabel
Nitrogen source and growth stage of Candida albicans influence expression level of vacuolar aspartic protease Apr1p and carboxypeptidase Cpy1p Nitrogen source and growth stage of Candida albicans influence expression level of vacuolar aspartic protease Apr1p and carboxypeptidase Cpy1p
skos:notation
RIV/61388963:_____/12:00379073!RIV13-AV0-61388963
n12:predkladatel
n13:ico%3A61388963
n3:aktivita
n17:Z n17:P
n3:aktivity
P(GA310/09/1945), P(LC531), Z(AV0Z40550506)
n3:cisloPeriodika
5
n3:dodaniDat
n5:2013
n3:domaciTvurceVysledku
n18:2264102 n18:5300169 n18:6949924
n3:druhVysledku
n19:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
154253
n3:idVysledku
RIV/61388963:_____/12:00379073
n3:jazykVysledku
n20:eng
n3:klicovaSlova
Candida albicans; carboxypeptidase Y; nitrogen starvation; vacuole
n3:klicoveSlovo
n11:Candida%20albicans n11:nitrogen%20starvation n11:carboxypeptidase%20Y n11:vacuole
n3:kodStatuVydavatele
CA - Kanada
n3:kontrolniKodProRIV
[BBB2DDDECFFE]
n3:nazevZdroje
Canadian Journal of Microbiology
n3:obor
n4:CE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n9:GA310%2F09%2F1945 n9:LC531
n3:rokUplatneniVysledku
n5:2012
n3:svazekPeriodika
58
n3:tvurceVysledku
Pichová, Iva Hrušková, Olga Bauerová, Václava
n3:wos
000303659500015
n3:zamer
n15:AV0Z40550506
s:issn
0008-4166
s:numberOfPages
4
n8:doi
10.1139/W2012-030