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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F12%3A00377926%21RIV13-AV0-61388963
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Automated RNA alignment algorithms often fail to recapture the essential conserved sites that are critical for function. To assist in the refinement of these algorithms, we manually curated a set of 148 alignments with a total of 9600 unique sequences, in which each alignment was backed by at least one crystal or NMR structure. These alignments included both naturally and artificially selected molecules. We used principles of isostericity to improve the alignments from an average of 83%-94% isosteric base pairs. We expect that this alignment collection will assist in a wide range of benchmarking efforts and provide new insight into evolutionary principles governing change in RNA structural motifs. The improved alignments have been contributed to the Rfam database. Automated RNA alignment algorithms often fail to recapture the essential conserved sites that are critical for function. To assist in the refinement of these algorithms, we manually curated a set of 148 alignments with a total of 9600 unique sequences, in which each alignment was backed by at least one crystal or NMR structure. These alignments included both naturally and artificially selected molecules. We used principles of isostericity to improve the alignments from an average of 83%-94% isosteric base pairs. We expect that this alignment collection will assist in a wide range of benchmarking efforts and provide new insight into evolutionary principles governing change in RNA structural motifs. The improved alignments have been contributed to the Rfam database.
dcterms:title
RNASTAR: An RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs RNASTAR: An RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs
skos:prefLabel
RNASTAR: An RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs RNASTAR: An RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs
skos:notation
RIV/61388963:_____/12:00377926!RIV13-AV0-61388963
n13:predkladatel
n14:ico%3A61388963
n4:aktivita
n8:Z n8:P
n4:aktivity
P(ME09019), Z(AV0Z40550506)
n4:cisloPeriodika
7
n4:dodaniDat
n15:2013
n4:domaciTvurceVysledku
n19:3237907
n4:druhVysledku
n10:J
n4:duvernostUdaju
n7:S
n4:entitaPredkladatele
n11:predkladatel
n4:idSjednocenehoVysledku
165809
n4:idVysledku
RIV/61388963:_____/12:00377926
n4:jazykVysledku
n17:eng
n4:klicovaSlova
RNA; RNASTAR; alignment; repository
n4:klicoveSlovo
n5:alignment n5:repository n5:RNA n5:RNASTAR
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[F87C58F75A3E]
n4:nazevZdroje
R N A
n4:obor
n6:CC
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
13
n4:projekt
n12:ME09019
n4:rokUplatneniVysledku
n15:2012
n4:svazekPeriodika
18
n4:tvurceVysledku
Wikman, S. Quinn, J. Stombaugh, J. Smit, S. Zaneveld, J. R. R. Liu, Z. Chocholoušová, Jana Iyer, M. Gardner, P. McDonald, D. Knight, R. Widmann, J. Lozupone, C. A.
n4:wos
000305349000002
n4:zamer
n20:AV0Z40550506
s:issn
1355-8382
s:numberOfPages
9
n18:doi
10.1261/rna.032052.111