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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F12%3A00377427%21RIV13-AV0-61388963
rdf:type
n13:Vysledek skos:Concept
dcterms:description
The review summarizes the basic milestones of research of 5-azacytosine nucleosides, and their mechanism of action as inhibitors of DNA methylations. Compounds decitabine and 5-azacytidine became clinically used drugs. The second part of the review is paid to 5-azacytosine acyclic nucleoside analogues and phosphonomethyl derivatives as anti-DNA virus agents. The review summarizes the basic milestones of research of 5-azacytosine nucleosides, and their mechanism of action as inhibitors of DNA methylations. Compounds decitabine and 5-azacytidine became clinically used drugs. The second part of the review is paid to 5-azacytosine acyclic nucleoside analogues and phosphonomethyl derivatives as anti-DNA virus agents.
dcterms:title
5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives 5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives
skos:prefLabel
5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives 5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives
skos:notation
RIV/61388963:_____/12:00377427!RIV13-AV0-61388963
n13:predkladatel
n14:ico%3A61388963
n3:aktivita
n10:P n10:I
n3:aktivity
I, P(FR-TI4/625)
n3:cisloPeriodika
8
n3:dodaniDat
n5:2013
n3:domaciTvurceVysledku
n18:5025702 n18:2758849
n3:druhVysledku
n11:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
183529
n3:idVysledku
RIV/61388963:_____/12:00377427
n3:jazykVysledku
n19:eng
n3:klicovaSlova
5-azacytidine; 2´-deoxy-5-azacytidine; hypomethylation; DAC; epigenetics; DNA methylation; acyclic nucleoside phosphonates; 5-azacytosine; HPMP-5-azacytosine; prodrugs
n3:klicoveSlovo
n4:5-azacytosine n4:epigenetics n4:prodrugs n4:acyclic%20nucleoside%20phosphonates n4:5-azacytidine n4:DNA%20methylation n4:2%C2%B4-deoxy-5-azacytidine n4:hypomethylation n4:HPMP-5-azacytosine n4:DAC
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[702B4E34ABDA]
n3:nazevZdroje
Future Medicinal Chemistry
n3:obor
n15:CC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n8:FR-TI4%2F625
n3:rokUplatneniVysledku
n5:2012
n3:svazekPeriodika
4
n3:tvurceVysledku
Krečmerová, Marcela Otmar, Miroslav
n3:wos
000304512000011
s:issn
1756-8919
s:numberOfPages
15
n9:doi
10.4155/FMC.12.36