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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F11%3A00366668%21RIV12-AV0-61388963
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Cathepsin D is an aspartic peptidase involved in cellular processes including proliferation and apoptosis. We describe a complex pattern of modulation of the peptidolytic activity of cathepsin D by sphingolipids. A panel of sphingolipid derivatives was screened in a FRET-based assay; these molecules demonstrated negative or positive modulation of cathepsin D peptidolytic activity, depending on the sphingolipid structure. Certain sphingosines and ceramides inhibited cathepsin D, and structural requirements for this inhibitory effect were evaluated. In contrast, monoester phosphosphingolipids, especially ceramide-1-phosphate, were identified as activators of cathepsin D peptidolytic activity Thus, sphingolipids and phosphosphingolipids, known to be antagonistic in their cell-signaling functions, displayed opposite modulation of cathepsin D. Cathepsin D is an aspartic peptidase involved in cellular processes including proliferation and apoptosis. We describe a complex pattern of modulation of the peptidolytic activity of cathepsin D by sphingolipids. A panel of sphingolipid derivatives was screened in a FRET-based assay; these molecules demonstrated negative or positive modulation of cathepsin D peptidolytic activity, depending on the sphingolipid structure. Certain sphingosines and ceramides inhibited cathepsin D, and structural requirements for this inhibitory effect were evaluated. In contrast, monoester phosphosphingolipids, especially ceramide-1-phosphate, were identified as activators of cathepsin D peptidolytic activity Thus, sphingolipids and phosphosphingolipids, known to be antagonistic in their cell-signaling functions, displayed opposite modulation of cathepsin D.
dcterms:title
Complex modulation of peptidolytic activity of cathepsin D by sphingolipids Complex modulation of peptidolytic activity of cathepsin D by sphingolipids
skos:prefLabel
Complex modulation of peptidolytic activity of cathepsin D by sphingolipids Complex modulation of peptidolytic activity of cathepsin D by sphingolipids
skos:notation
RIV/61388963:_____/11:00366668!RIV12-AV0-61388963
n9:predkladatel
n14:ico%3A61388963
n3:aktivita
n16:Z n16:S n16:P
n3:aktivity
P(IAA400550705), S, Z(AV0Z40550506)
n3:cisloPeriodika
12
n3:dodaniDat
n19:2012
n3:domaciTvurceVysledku
n5:8365423 n5:8360510 n5:7831951 n5:9846476 n5:8133859
n3:druhVysledku
n18:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
191400
n3:idVysledku
RIV/61388963:_____/11:00366668
n3:jazykVysledku
n20:eng
n3:klicovaSlova
sphingolipid; phospholipid; inhibition; activation; cathepsin D; enzyme regulation
n3:klicoveSlovo
n4:inhibition n4:cathepsin%20D n4:sphingolipid n4:activation n4:enzyme%20regulation n4:phospholipid
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[C611D6C0D23C]
n3:nazevZdroje
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids
n3:obor
n7:CE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:projekt
n11:IAA400550705
n3:rokUplatneniVysledku
n19:2011
n3:svazekPeriodika
1811
n3:tvurceVysledku
Máša, Martin Mareš, Michael Horn, Martin Žebrakovská, Iva Vávrová, K. Srp, Jaroslav
n3:wos
000298521700012
n3:zamer
n12:AV0Z40550506
s:issn
1388-1981
s:numberOfPages
8
n15:doi
10.1016/j.bbalip.2011.09.005