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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F11%3A00361001%21RIV12-AV0-61388963
rdf:type
n3:Vysledek skos:Concept
dcterms:description
We recently introduced a furan-oxidation-based methodology for crosslinking of nucleic acids. Given the destabilization of duplexes observed upon introduction of the initially designed furan-modified building block into DNA duplexes, we explore here the potential benefits of two new building blocks featuring an extended aromatic system and a restored cyclic backbone. Thorough experimental analysis of crosslinking reactions in a series of contexts, combined with theoretical calculations, permit structural characterization of the formed species and allow assessment of the origin of the enhanced cross-link selectivity. Our experiments clearly show that the modular nature of the furan-modified building blocks used in the current cross-linking strategy allow for fine tuning of both yield and selectivity of the interstrand crosslinking reaction. We recently introduced a furan-oxidation-based methodology for crosslinking of nucleic acids. Given the destabilization of duplexes observed upon introduction of the initially designed furan-modified building block into DNA duplexes, we explore here the potential benefits of two new building blocks featuring an extended aromatic system and a restored cyclic backbone. Thorough experimental analysis of crosslinking reactions in a series of contexts, combined with theoretical calculations, permit structural characterization of the formed species and allow assessment of the origin of the enhanced cross-link selectivity. Our experiments clearly show that the modular nature of the furan-modified building blocks used in the current cross-linking strategy allow for fine tuning of both yield and selectivity of the interstrand crosslinking reaction.
dcterms:title
Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks-On the Benefit of Restoring the Cyclic Sugar Backbone Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks-On the Benefit of Restoring the Cyclic Sugar Backbone
skos:prefLabel
Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks-On the Benefit of Restoring the Cyclic Sugar Backbone Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks-On the Benefit of Restoring the Cyclic Sugar Backbone
skos:notation
RIV/61388963:_____/11:00361001!RIV12-AV0-61388963
n3:predkladatel
n4:ico%3A61388963
n6:aktivita
n12:P n12:Z
n6:aktivity
P(IAA400550902), P(LC512), Z(AV0Z40550506)
n6:cisloPeriodika
25
n6:dodaniDat
n7:2012
n6:domaciTvurceVysledku
n14:6659160
n6:druhVysledku
n11:J
n6:duvernostUdaju
n16:S
n6:entitaPredkladatele
n13:predkladatel
n6:idSjednocenehoVysledku
200655
n6:idVysledku
RIV/61388963:_____/11:00361001
n6:jazykVysledku
n10:eng
n6:klicovaSlova
bioorganic chemistry; DNA; molecular modeling; nucleosides; oxidation
n6:klicoveSlovo
n8:molecular%20modeling n8:nucleosides n8:oxidation n8:bioorganic%20chemistry n8:DNA
n6:kodStatuVydavatele
DE - Spolková republika Německo
n6:kontrolniKodProRIV
[3EA671E05202]
n6:nazevZdroje
Chemistry - A European Journal
n6:obor
n20:CC
n6:pocetDomacichTvurcuVysledku
1
n6:pocetTvurcuVysledku
9
n6:projekt
n9:IAA400550902 n9:LC512
n6:rokUplatneniVysledku
n7:2011
n6:svazekPeriodika
17
n6:tvurceVysledku
Speybroeck, V. V. Stevens, K. Catak, S. Schürch, S. Hocek, Michal Claeys, D. D. Figaroli, S. Madder, A. Tromp, J. M.
n6:wos
000292206600011
n6:zamer
n19:AV0Z40550506
s:issn
0947-6539
s:numberOfPages
14
n15:doi
10.1002/chem.201100067