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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F11%3A00359135%21RIV12-MZ0-61388963
rdf:type
n12:Vysledek skos:Concept
dcterms:description
This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found. This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found.
dcterms:title
The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases
skos:prefLabel
The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases
skos:notation
RIV/61388963:_____/11:00359135!RIV12-MZ0-61388963
n12:predkladatel
n18:ico%3A61388963
n3:aktivita
n11:P n11:Z
n3:aktivity
P(2B06065), P(LC06077), P(NR9138), Z(AV0Z40550506)
n3:cisloPeriodika
7
n3:dodaniDat
n8:2012
n3:domaciTvurceVysledku
n13:1570889 n13:7137370 n13:8683387
n3:druhVysledku
n9:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
233913
n3:idVysledku
RIV/61388963:_____/11:00359135
n3:jazykVysledku
n17:eng
n3:klicovaSlova
piperidine derivatives; nucleoside analogs; nucleobase; proline
n3:klicoveSlovo
n7:nucleobase n7:nucleoside%20analogs n7:proline n7:piperidine%20derivatives
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[BAB815F1A49D]
n3:nazevZdroje
Tetrahedron
n3:obor
n5:CC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n15:NR9138 n15:2B06065 n15:LC06077
n3:rokUplatneniVysledku
n8:2011
n3:svazekPeriodika
67
n3:tvurceVysledku
Dračínský, Martin Rejman, Dominik Kovačková, Soňa
n3:wos
000287340600013
n3:zamer
n6:AV0Z40550506
s:issn
0040-4020
s:numberOfPages
16
n20:doi
10.1016/j.tet.2010.12.029