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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F10%3A00353675%21RIV11-MSM-61388963
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Since new and dangerous influenza virus strains, such as H5N1 %22avian flu%22 and more recently the swine-origin H1N1 %22swine flu%22, are constantly evolving, the need for effective anti-influenza drugs is pressing. It is becoming clear that the emergence of drug-resistant viruses will be a major potential problem in future efforts to control influenza virus infection. Moreover, development of vaccines against new influenza strains takes several months, and their production capacity is limited. Thus, new classes of anti-influenza drugs are highly sought after. This review focuses mainly on novel strategies, including targeting viral entry into host cells, inhibition of viral transcription and genome replication, and targeting of the NS1 influenza protein. Another approach involves viral RNA silencing by siRNAs or by antisense oligonucleotides. Since new and dangerous influenza virus strains, such as H5N1 %22avian flu%22 and more recently the swine-origin H1N1 %22swine flu%22, are constantly evolving, the need for effective anti-influenza drugs is pressing. It is becoming clear that the emergence of drug-resistant viruses will be a major potential problem in future efforts to control influenza virus infection. Moreover, development of vaccines against new influenza strains takes several months, and their production capacity is limited. Thus, new classes of anti-influenza drugs are highly sought after. This review focuses mainly on novel strategies, including targeting viral entry into host cells, inhibition of viral transcription and genome replication, and targeting of the NS1 influenza protein. Another approach involves viral RNA silencing by siRNAs or by antisense oligonucleotides.
dcterms:title
Therapeutic Targets for Influenza - Perspectives in Drug Development Therapeutic Targets for Influenza - Perspectives in Drug Development
skos:prefLabel
Therapeutic Targets for Influenza - Perspectives in Drug Development Therapeutic Targets for Influenza - Perspectives in Drug Development
skos:notation
RIV/61388963:_____/10:00353675!RIV11-MSM-61388963
n3:aktivita
n13:Z n13:P
n3:aktivity
P(1M0508), Z(AV0Z40550506)
n3:cisloPeriodika
1
n3:dodaniDat
n11:2011
n3:domaciTvurceVysledku
n18:6922236
n3:druhVysledku
n16:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
292684
n3:idVysledku
RIV/61388963:_____/10:00353675
n3:jazykVysledku
n4:eng
n3:klicovaSlova
influenza; drug research; protein structure; oligonucleotides
n3:klicoveSlovo
n8:oligonucleotides n8:protein%20structure n8:drug%20research n8:influenza
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[5DF135AC65F2]
n3:nazevZdroje
Collection of Czechoslovak Chemical Communications
n3:obor
n9:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:projekt
n15:1M0508
n3:rokUplatneniVysledku
n11:2010
n3:svazekPeriodika
75
n3:tvurceVysledku
Majerová, Taťána Hoffman, H. Majer, F.
n3:wos
000274668100005
n3:zamer
n17:AV0Z40550506
s:issn
0010-0765
s:numberOfPages
23