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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F10%3A00351324%21RIV11-GA0-61388963
rdf:type
n9:Vysledek skos:Concept
dcterms:description
The influence of dimerization and tetramerization of peptide melectin (GFLSILKKVLPKVMAHMK-NH2) on its antimicrobial and hemolytic activities, as well as the role of Met in positions 14 and 17 of its peptide chain, was studied. 23 new analogues were synthesized. Dimerization and tetramerization increased the undesirable hemolytic activity. Introduction of the isosteric amino acid Nle into positions 14 or 17 or both led to only slight increase of hemolytic activity under preservation of high antimicrobial activities. Substitution of Leu for Val in position 6 led to the decrease of hemolytic activity. The influence of dimerization and tetramerization of peptide melectin (GFLSILKKVLPKVMAHMK-NH2) on its antimicrobial and hemolytic activities, as well as the role of Met in positions 14 and 17 of its peptide chain, was studied. 23 new analogues were synthesized. Dimerization and tetramerization increased the undesirable hemolytic activity. Introduction of the isosteric amino acid Nle into positions 14 or 17 or both led to only slight increase of hemolytic activity under preservation of high antimicrobial activities. Substitution of Leu for Val in position 6 led to the decrease of hemolytic activity.
dcterms:title
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity
skos:prefLabel
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity
skos:notation
RIV/61388963:_____/10:00351324!RIV11-GA0-61388963
n3:aktivita
n13:P n13:Z
n3:aktivity
P(GA203/03/1362), P(GA203/09/1919), Z(AV0Z40550506)
n3:cisloPeriodika
5
n3:dodaniDat
n15:2011
n3:domaciTvurceVysledku
n4:6590454 n4:3677672 n4:5602955 Ehala, Sille n4:9667598 n4:6236219 n4:2935570 n4:4706633 n4:3886875 n4:5281644
n3:druhVysledku
n14:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
270309
n3:idVysledku
RIV/61388963:_____/10:00351324
n3:jazykVysledku
n11:eng
n3:klicovaSlova
melectin; antibacterial peptides; dendrimers; hemolytic activity
n3:klicoveSlovo
n12:antibacterial%20peptides n12:hemolytic%20activity n12:melectin n12:dendrimers
n3:kodStatuVydavatele
AT - Rakouská republika
n3:kontrolniKodProRIV
[FBE6C688CB1C]
n3:nazevZdroje
Amino Acids
n3:obor
n6:CC
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
10
n3:projekt
n8:GA203%2F03%2F1362 n8:GA203%2F09%2F1919
n3:rokUplatneniVysledku
n15:2010
n3:svazekPeriodika
39
n3:tvurceVysledku
Borovičková, Lenka Slaninová, Jiřina Fučík, Vladimír Buděšínský, Miloš Šafařík, Martin Čeřovský, Václav Niederhafner, Petr Ehala, Sille Ježek, Jan Bednárová, Lucie
n3:wos
000283502900044
n3:zamer
n7:AV0Z40550506
s:issn
0939-4451
s:numberOfPages
9