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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F10%3A00350071%21RIV11-MSM-61388963
rdf:type
n11:Vysledek skos:Concept
dcterms:description
A series of cycloSal-phosphate prodrugs of a recently described new class of nucleoside cytostatics (6-hetaryl-7-deazapurine ribonucleosides) was prepared. The in vitro cytostatic effect of the pronucleotides was compared with parent nucleoside analogues. In most cases, the activity of the pronucleotide was similar to or somewhat lower than that of the corresponding parent nucleosides. A series of cycloSal-phosphate prodrugs of a recently described new class of nucleoside cytostatics (6-hetaryl-7-deazapurine ribonucleosides) was prepared. The in vitro cytostatic effect of the pronucleotides was compared with parent nucleoside analogues. In most cases, the activity of the pronucleotide was similar to or somewhat lower than that of the corresponding parent nucleosides.
dcterms:title
CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases
skos:prefLabel
CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases
skos:notation
RIV/61388963:_____/10:00350071!RIV11-MSM-61388963
n4:aktivita
n12:P n12:Z
n4:aktivity
P(1M0508), Z(AV0Z40550506)
n4:cisloPeriodika
8
n4:dodaniDat
n17:2011
n4:domaciTvurceVysledku
n9:8571325 n9:2264102 n9:6998798 n9:6659160 n9:3603652 n9:8555346 n9:1703404 n9:4342771
n4:druhVysledku
n13:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
252608
n4:idVysledku
RIV/61388963:_____/10:00350071
n4:jazykVysledku
n6:eng
n4:klicovaSlova
nucleosides; pronucleotides; deazapurines; cytostatics
n4:klicoveSlovo
n7:pronucleotides n7:deazapurines n7:nucleosides n7:cytostatics
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[77B66950586D]
n4:nazevZdroje
ChemMedChem
n4:obor
n14:CC
n4:pocetDomacichTvurcuVysledku
8
n4:pocetTvurcuVysledku
11
n4:projekt
n18:1M0508
n4:rokUplatneniVysledku
n17:2010
n4:svazekPeriodika
5
n4:tvurceVysledku
Birkuš, G. Zábranská, Helena Spáčilová, Pavla Pichová, Iva Snášel, Jan Ameral, R. Pohl, Radek Nauš, Petr Hocek, Michal Votruba, Ivan Cihlař, T.
n4:wos
000281061300023
n4:zamer
n15:AV0Z40550506
s:issn
1860-7179
s:numberOfPages
11