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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F10%3A00346305%21RIV11-MSM-61388963
rdf:type
skos:Concept n18:Vysledek
dcterms:description
9-[2-(phosphonomethoxy)ethyl] guanine (PMEG) is a guanine acyclic nucleotide analog whose prodrugs are being investigated for chemotherapy of lymphomas. The objective of this study was to determine the requirements for caspase and CD95/Fas activation in PMEG-induced apoptosis and the influence of PMEG on cell cycle regulatory proteins in CCRF-CEM cells. As for cell cycle regulation, cyclin E1 was found to be up-regulated following PMEG treatment. Although an increase of caspase 3, 8 and 9 proteolytic activity was observed, neither pretreatment of the cells with cell-permeable caspase inhibitors nor blocking the death receptor with anti-Fas antibody did prevent apoptosis induced by PMEG. It was concluded that PMEG-induced apoptosis is caspase- and CD95/Fas-independent. 9-[2-(phosphonomethoxy)ethyl] guanine (PMEG) is a guanine acyclic nucleotide analog whose prodrugs are being investigated for chemotherapy of lymphomas. The objective of this study was to determine the requirements for caspase and CD95/Fas activation in PMEG-induced apoptosis and the influence of PMEG on cell cycle regulatory proteins in CCRF-CEM cells. As for cell cycle regulation, cyclin E1 was found to be up-regulated following PMEG treatment. Although an increase of caspase 3, 8 and 9 proteolytic activity was observed, neither pretreatment of the cells with cell-permeable caspase inhibitors nor blocking the death receptor with anti-Fas antibody did prevent apoptosis induced by PMEG. It was concluded that PMEG-induced apoptosis is caspase- and CD95/Fas-independent.
dcterms:title
Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells
skos:prefLabel
Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells
skos:notation
RIV/61388963:_____/10:00346305!RIV11-MSM-61388963
n4:aktivita
n12:Z n12:P
n4:aktivity
P(1M0508), Z(AV0Z40550506)
n4:cisloPeriodika
7
n4:dodaniDat
n5:2011
n4:domaciTvurceVysledku
n8:8571325 n8:8255946 Matoušová, Marika n8:9587217 n8:7359608
n4:druhVysledku
n17:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
285683
n4:idVysledku
RIV/61388963:_____/10:00346305
n4:jazykVysledku
n16:eng
n4:klicovaSlova
acyclic nucleoside phosphonate; programmed cell death; CCRF-CEM cells; cell cycle
n4:klicoveSlovo
n6:programmed%20cell%20death n6:cell%20cycle n6:acyclic%20nucleoside%20phosphonate n6:CCRF-CEM%20cells
n4:kodStatuVydavatele
GR - Řecká republika
n4:kontrolniKodProRIV
[181DCABFC0B6]
n4:nazevZdroje
Anticancer Research
n4:obor
n7:CC
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
5
n4:projekt
n11:1M0508
n4:rokUplatneniVysledku
n5:2010
n4:svazekPeriodika
30
n4:tvurceVysledku
Holý, Antonín Mertlíková-Kaiserová, Helena Hájek, Miroslav Votruba, Ivan Matoušová, Marika
n4:wos
000280796400043
n4:zamer
n14:AV0Z40550506
s:issn
0250-7005
s:numberOfPages
8