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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F10%3A00346304%21RIV11-MSM-61388963
rdf:type
skos:Concept n13:Vysledek
dcterms:description
We have previously shown that PMEG diphosphate and PMEDAP diphosphate inhibit the enzymatic activity of human telomerase in a cell-free assay. Here, we investigated the ability of PMEG and PMEDAP to induce telomere shortening and telomerase inhibition in two T-cell leukemia cell lines. Both PMEDAP and PMEG induced telomere shortening in CCRF-CEM cells after 9 weeks of exposure while the effect of the compounds on telomere length in MOLT-4 cells was the opposite. No correlation between telomerase activity and telomere length was found. Both compounds also down-regulated the expression of hTERT and c-myc mRNA in both cell lines. In conclusion, PMEDAP and PMEG are able to modulate telomere length in leukemic cells and this effect is cell-type specific. It is neither due to telomerase inhibition nor impairment of hTERT expression and it is likely to be telomerase-independent. We have previously shown that PMEG diphosphate and PMEDAP diphosphate inhibit the enzymatic activity of human telomerase in a cell-free assay. Here, we investigated the ability of PMEG and PMEDAP to induce telomere shortening and telomerase inhibition in two T-cell leukemia cell lines. Both PMEDAP and PMEG induced telomere shortening in CCRF-CEM cells after 9 weeks of exposure while the effect of the compounds on telomere length in MOLT-4 cells was the opposite. No correlation between telomerase activity and telomere length was found. Both compounds also down-regulated the expression of hTERT and c-myc mRNA in both cell lines. In conclusion, PMEDAP and PMEG are able to modulate telomere length in leukemic cells and this effect is cell-type specific. It is neither due to telomerase inhibition nor impairment of hTERT expression and it is likely to be telomerase-independent.
dcterms:title
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP
skos:prefLabel
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP
skos:notation
RIV/61388963:_____/10:00346304!RIV11-MSM-61388963
n3:aktivita
n4:P n4:Z
n3:aktivity
P(1M0508), P(1QS400550501), Z(AV0Z40550506)
n3:cisloPeriodika
1
n3:dodaniDat
n14:2011
n3:domaciTvurceVysledku
n5:8255946 n5:9587217 n5:7359608 n5:8571325 n5:7480679
n3:druhVysledku
n8:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
254690
n3:idVysledku
RIV/61388963:_____/10:00346304
n3:jazykVysledku
n7:eng
n3:klicovaSlova
acyclic nucleoside phosphonates; PMEG; PMEDAP; telomere length; telomerase inhibition
n3:klicoveSlovo
n11:PMEDAP n11:PMEG n11:telomerase%20inhibition n11:telomere%20length n11:acyclic%20nucleoside%20phosphonates
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[0BE43D9D56E7]
n3:nazevZdroje
European Journal of Pharmacology
n3:obor
n15:CC
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n16:1QS400550501 n16:1M0508
n3:rokUplatneniVysledku
n14:2010
n3:svazekPeriodika
643
n3:tvurceVysledku
Mertlíková-Kaiserová, Helena Hájek, Miroslav Votruba, Ivan Cvilink, Viktor Holý, Antonín
n3:wos
000280627700002
n3:zamer
n10:AV0Z40550506
s:issn
0014-2999
s:numberOfPages
7