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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F10%3A00345886%21RIV11-MSM-61388963
rdf:type
skos:Concept n10:Vysledek
dcterms:description
For protozoan parasites, 6-oxopurine phosphoribosyltransferases (PRTases) provide the only metabolic pathway to synthesize the purine nucleoside monophosphates essential for DNA/RNA production. This enzyme from Plasmodium vivax was cloned, expressed and purified and its properties compared with those of the corresponding enzymes from human and P. falciparum. Several acyclic nucleoside phosphonates were evaluated as inhibitors of PvHGPRT giving Ki values as low as 0.5 .mu.M. For protozoan parasites, 6-oxopurine phosphoribosyltransferases (PRTases) provide the only metabolic pathway to synthesize the purine nucleoside monophosphates essential for DNA/RNA production. This enzyme from Plasmodium vivax was cloned, expressed and purified and its properties compared with those of the corresponding enzymes from human and P. falciparum. Several acyclic nucleoside phosphonates were evaluated as inhibitors of PvHGPRT giving Ki values as low as 0.5 .mu.M.
dcterms:title
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy
skos:prefLabel
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy
skos:notation
RIV/61388963:_____/10:00345886!RIV11-MSM-61388963
n3:aktivita
n14:P n14:Z
n3:aktivity
P(1M0508), Z(AV0Z40550506)
n3:cisloPeriodika
2
n3:dodaniDat
n16:2011
n3:domaciTvurceVysledku
n5:9587217 n5:5025702 n5:9345655 n5:1675877
n3:druhVysledku
n13:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
279138
n3:idVysledku
RIV/61388963:_____/10:00345886
n3:jazykVysledku
n8:eng
n3:klicovaSlova
acyclic nucleoside phosphonates; Plasmodium vivax; 6-oxopurine phosphoribosyltransferase
n3:klicoveSlovo
n11:acyclic%20nucleoside%20phosphonates n11:Plasmodium%20vivax n11:6-oxopurine%20phosphoribosyltransferase
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[39BF74319FFC]
n3:nazevZdroje
Molecular and Biochemical Parasitology
n3:obor
n17:CC
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
10
n3:projekt
n15:1M0508
n3:rokUplatneniVysledku
n16:2010
n3:svazekPeriodika
173
n3:tvurceVysledku
Holý, Antonín Keough, D. T. Česnek, Michal Krečmerová, Marcela Naesens, L. Guddat, L. W. de Jersey, J. Winzor, D. J. Brereton, I. M. Hocková, Dana
n3:wos
000280659300015
n3:zamer
n12:AV0Z40550506
s:issn
0166-6851
s:numberOfPages
5