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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F10%3A00342359%21RIV11-GA0-61388963
rdf:type
skos:Concept n6:Vysledek
dcterms:description
Sonogashira cross-coupling reactions of 5-iodopyrimidine or 7-iodo-7-deazaadenine nucleosides with bile acid-derived terminal acetylenes gave the corresponding bile acid-nucleoside conjugates. Analogous reactions of halogenated nucleoside triphosphates gave directly bile acid-modified dNTPs. Enzymatic incorporation of these modified nucleotides to DNA was successfully performed using Phusion polymerase for primer extension. Sonogashira cross-coupling reactions of 5-iodopyrimidine or 7-iodo-7-deazaadenine nucleosides with bile acid-derived terminal acetylenes gave the corresponding bile acid-nucleoside conjugates. Analogous reactions of halogenated nucleoside triphosphates gave directly bile acid-modified dNTPs. Enzymatic incorporation of these modified nucleotides to DNA was successfully performed using Phusion polymerase for primer extension.
dcterms:title
Synthesis of nucleoside and nucleotide conjugates of bile acids, and polymerase construction of bile acid-functionalized DNA Synthesis of nucleoside and nucleotide conjugates of bile acids, and polymerase construction of bile acid-functionalized DNA
skos:prefLabel
Synthesis of nucleoside and nucleotide conjugates of bile acids, and polymerase construction of bile acid-functionalized DNA Synthesis of nucleoside and nucleotide conjugates of bile acids, and polymerase construction of bile acid-functionalized DNA
skos:notation
RIV/61388963:_____/10:00342359!RIV11-GA0-61388963
n3:aktivita
n11:P n11:Z
n3:aktivity
P(GA203/09/0317), P(LC512), Z(AV0Z40550506)
n3:cisloPeriodika
5
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n7:2810824 n7:3603652 n7:2396955 Ikonen, Satu n7:6659160
n3:druhVysledku
n8:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
291541
n3:idVysledku
RIV/61388963:_____/10:00342359
n3:jazykVysledku
n14:eng
n3:klicovaSlova
steroids; nucleosides; nucleoside triphosphates; DNA polymerase
n3:klicoveSlovo
n10:nucleoside%20triphosphates n10:nucleosides n10:DNA%20polymerase n10:steroids
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[11416A737408]
n3:nazevZdroje
Organic & Biomolecular Chemistry
n3:obor
n12:CC
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n4:LC512 n4:GA203%2F09%2F0317
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
8
n3:tvurceVysledku
Šanda, Miloslav Hocek, Michal Macíčková-Cahová, Hana Pohl, Radek Ikonen, Satu
n3:wos
000275100100033
n3:zamer
n15:AV0Z40550506
s:issn
1477-0520
s:numberOfPages
8