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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F10%3A00342338%21RIV11-MSM-61388963
rdf:type
n9:Vysledek skos:Concept
dcterms:description
A series of novel 7-deazapurine ribonucleosides bearing an alkyl, aryl or hetaryl group in position 6 and H, F, or Cl atom in position 7 has been prepared and showed to possess significant cytostatic effect in nanomolar concentrations. Intracellular phosphorylation to mono- and triphosphates, and the inhibition of total RNA synthesis was demonstrated in preliminary study of metabolism and mechanism of action studies. A series of novel 7-deazapurine ribonucleosides bearing an alkyl, aryl or hetaryl group in position 6 and H, F, or Cl atom in position 7 has been prepared and showed to possess significant cytostatic effect in nanomolar concentrations. Intracellular phosphorylation to mono- and triphosphates, and the inhibition of total RNA synthesis was demonstrated in preliminary study of metabolism and mechanism of action studies.
dcterms:title
6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents
skos:prefLabel
6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents
skos:notation
RIV/61388963:_____/10:00342338!RIV11-MSM-61388963
n4:aktivita
n14:Z n14:S n14:P
n4:aktivity
P(1M0508), P(1QS400550501), S, Z(AV0Z40550506)
n4:cisloPeriodika
1
n4:dodaniDat
n8:2011
n4:domaciTvurceVysledku
n12:6659160 n12:3603652 n12:8555346 n12:8571325
n4:druhVysledku
n18:J
n4:duvernostUdaju
n6:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
301043
n4:idVysledku
RIV/61388963:_____/10:00342338
n4:jazykVysledku
n15:eng
n4:klicovaSlova
nucleosides; 7-deazapurines; cross-coupling; cytostatic activity
n4:klicoveSlovo
n5:cross-coupling n5:7-deazapurines n5:nucleosides n5:cytostatic%20activity
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[23E63D2BAA98]
n4:nazevZdroje
Journal of Medicinal Chemistry
n4:obor
n7:CC
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
12
n4:projekt
n10:1M0508 n10:1QS400550501
n4:rokUplatneniVysledku
n8:2010
n4:svazekPeriodika
53
n4:tvurceVysledku
Cihlar, T. Džubák, P. Birkuš, G. Nauš, Petr Ameral, R. Ray, A. S. Hajdúch, M. Votruba, Ivan Pohl, Radek Hocek, Michal Mackman, R. Wang, T.
n4:wos
000273268300039
n4:zamer
n17:AV0Z40550506
s:issn
0022-2623
s:numberOfPages
11