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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F09%3A00336551%21RIV11-MSM-61388963
rdf:type
n14:Vysledek skos:Concept
dcterms:description
This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced, as well as alternative approaches, aiming at other functional domains of HIV PR. The potential of these novel compounds to open new way to the rational drug design of human viruses is critically assessed. This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced, as well as alternative approaches, aiming at other functional domains of HIV PR. The potential of these novel compounds to open new way to the rational drug design of human viruses is critically assessed.
dcterms:title
Current and Novel Inhibitors of HIV Protease Current and Novel Inhibitors of HIV Protease
skos:prefLabel
Current and Novel Inhibitors of HIV Protease Current and Novel Inhibitors of HIV Protease
skos:notation
RIV/61388963:_____/09:00336551!RIV11-MSM-61388963
n3:aktivita
n4:P n4:Z
n3:aktivity
P(1M0508), P(IAAX00320901), Z(AV0Z40550506)
n3:cisloPeriodika
3
n3:dodaniDat
n15:2011
n3:domaciTvurceVysledku
n6:7120532 n6:3056074 n6:6745725
n3:druhVysledku
n17:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
308700
n3:idVysledku
RIV/61388963:_____/09:00336551
n3:jazykVysledku
n7:eng
n3:klicovaSlova
HIV protease; protease inhibitor; HAART
n3:klicoveSlovo
n11:HIV%20protease n11:HAART n11:protease%20inhibitor
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[4D689E9622CF]
n3:nazevZdroje
Viruses
n3:obor
n10:CE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n12:1M0508 n12:IAAX00320901
n3:rokUplatneniVysledku
n15:2009
n3:svazekPeriodika
1
n3:tvurceVysledku
Konvalinka, Jan Řezáčová, Pavlína Pokorná, Jana Machala, L.
n3:wos
000280413200044
n3:zamer
n18:AV0Z40550506
s:issn
1999-4915
s:numberOfPages
31