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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F09%3A00333523%21RIV10-MSM-61388963
rdf:type
skos:Concept n18:Vysledek
dcterms:description
HIV integrase (IN) catalyzes the insertion of proviral DNA into the host cell chromosome. The integration site preference has been shown to be very diverse. We mapped the HIV integrase strand transfer reaction requirements using various short oligonucleotides (ON) that mimic the target DNA. We tested double stranded DNA dodecamers and hairpin-loop-forming oligonucleotides of different length. The integration biases with all target DNA structures tested were significantly influenced by changes in the resulting secondary ON structures. HIV integrase (IN) catalyzes the insertion of proviral DNA into the host cell chromosome. The integration site preference has been shown to be very diverse. We mapped the HIV integrase strand transfer reaction requirements using various short oligonucleotides (ON) that mimic the target DNA. We tested double stranded DNA dodecamers and hairpin-loop-forming oligonucleotides of different length. The integration biases with all target DNA structures tested were significantly influenced by changes in the resulting secondary ON structures.
dcterms:title
Mapping of HIV-1 integrase preferences for target site selection with various oligonucleotides Mapping of HIV-1 integrase preferences for target site selection with various oligonucleotides
skos:prefLabel
Mapping of HIV-1 integrase preferences for target site selection with various oligonucleotides Mapping of HIV-1 integrase preferences for target site selection with various oligonucleotides
skos:notation
RIV/61388963:_____/09:00333523!RIV10-MSM-61388963
n3:aktivita
n7:P n7:Z
n3:aktivity
P(1M0508), P(LC06077), Z(AV0Z40550506)
n3:cisloPeriodika
2
n3:dodaniDat
n13:2010
n3:domaciTvurceVysledku
n4:4342771 n4:4235010 n4:9843086 n4:2264102
n3:druhVysledku
n8:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
324680
n3:idVysledku
RIV/61388963:_____/09:00333523
n3:jazykVysledku
n17:eng
n3:klicovaSlova
HIV integrase; strand transfer reaction; oligonucleotide substrates
n3:klicoveSlovo
n5:strand%20transfer%20reaction n5:oligonucleotide%20substrates n5:HIV%20integrase
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[8568DC07A2FF]
n3:nazevZdroje
Archives of Biochemistry and Biophysics
n3:obor
n11:CE
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n15:1M0508 n15:LC06077
n3:rokUplatneniVysledku
n13:2009
n3:svazekPeriodika
488
n3:tvurceVysledku
Pačes, Ondřej Rosenberg, Ivan Snášel, Jan Pichová, Iva
n3:wos
000272541000009
n3:zamer
n14:AV0Z40550506
s:issn
0003-9861
s:numberOfPages
10