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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F09%3A00333023%21RIV10-MSM-61388963
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The study reports of several functional complexes of recombinant human GCPIII that allow for a direct comparison with equivalent GCPII complexes. That reveals differences in the organization of specificity pockets, in surface charge distribution, and in the occupancy of the co-catalytic zinc sites. The data presented here provide information that should prove to be essential for the structurally- aided design of GCPIII-specific ligands. The study reports of several functional complexes of recombinant human GCPIII that allow for a direct comparison with equivalent GCPII complexes. That reveals differences in the organization of specificity pockets, in surface charge distribution, and in the occupancy of the co-catalytic zinc sites. The data presented here provide information that should prove to be essential for the structurally- aided design of GCPIII-specific ligands.
dcterms:title
Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
skos:prefLabel
Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
skos:notation
RIV/61388963:_____/09:00333023!RIV10-MSM-61388963
n3:aktivita
n4:Z n4:P
n3:aktivity
P(1M0508), Z(AV0Z40550506)
n3:cisloPeriodika
16
n3:dodaniDat
n9:2010
n3:domaciTvurceVysledku
n5:7120532 n5:4552008
n3:druhVysledku
n11:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
344149
n3:idVysledku
RIV/61388963:_____/09:00333023
n3:jazykVysledku
n14:eng
n3:klicovaSlova
GCPIII; NAALADase II; metallopeptidase
n3:klicoveSlovo
n6:metallopeptidase n6:GCPIII n6:NAALADase%20II
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[2E42548335AC]
n3:nazevZdroje
FEBS Journal
n3:obor
n16:CE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n17:1M0508
n3:rokUplatneniVysledku
n9:2009
n3:svazekPeriodika
276
n3:tvurceVysledku
Hlouchová, Klára Lubkowski, J. Bařinka, C. Konvalinka, Jan
n3:wos
000268466600016
n3:zamer
n18:AV0Z40550506
s:issn
1742-464X
s:numberOfPages
15