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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F09%3A00330906%21RIV10-MSM-61388963
rdf:type
n13:Vysledek skos:Concept
dcterms:description
A number of new 5-aryl substituted pyrimidine acyclic nucleoside phosphonates were synthesized and tested for their ability to inhibit human TP. Their rapid synthesis using Pd-catalyzed Suzuki-Miyaura coupling reactions of various arylboronic acids with 5-bromo-4-(phosphonomethoxy)-2,6-dibutoxypyrimidine was succesfully applied. For a series of 5-aryl-6-phosphonomethoxyuracils, an increased inhibitory effect was determined. This effect is supported by the results found for 4-fluorophenyl (KidThd = 4.89 0.62) and 3-nitrophenyl (KidThd = 3.98 0.46) substituents. A number of new 5-aryl substituted pyrimidine acyclic nucleoside phosphonates were synthesized and tested for their ability to inhibit human TP. Their rapid synthesis using Pd-catalyzed Suzuki-Miyaura coupling reactions of various arylboronic acids with 5-bromo-4-(phosphonomethoxy)-2,6-dibutoxypyrimidine was succesfully applied. For a series of 5-aryl-6-phosphonomethoxyuracils, an increased inhibitory effect was determined. This effect is supported by the results found for 4-fluorophenyl (KidThd = 4.89 0.62) and 3-nitrophenyl (KidThd = 3.98 0.46) substituents.
dcterms:title
Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase
skos:prefLabel
Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase
skos:notation
RIV/61388963:_____/09:00330906!RIV10-MSM-61388963
n4:aktivita
n12:Z n12:P
n4:aktivity
P(1M0508), P(1QS400550501), Z(AV0Z40550506)
n4:cisloPeriodika
41
n4:dodaniDat
n10:2010
n4:domaciTvurceVysledku
n9:4195205 n9:9587217 n9:3603652 n9:3452905
n4:druhVysledku
n17:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
347913
n4:idVysledku
RIV/61388963:_____/09:00330906
n4:jazykVysledku
n5:eng
n4:klicovaSlova
acyclic nucleoside phosphonates; Suzuki-Miyaura reaction; thymidine phosphorylase; human thymidine phosphorylase
n4:klicoveSlovo
n11:human%20thymidine%20phosphorylase n11:thymidine%20phosphorylase n11:acyclic%20nucleoside%20phosphonates n11:Suzuki-Miyaura%20reaction
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[73DAFEA2FF3D]
n4:nazevZdroje
Tetrahedron
n4:obor
n7:CC
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
4
n4:projekt
n8:1QS400550501 n8:1M0508
n4:rokUplatneniVysledku
n10:2009
n4:svazekPeriodika
65
n4:tvurceVysledku
Pohl, Radek Horská, Květoslava Pomeisl, Karel Holý, Antonín
n4:wos
000270345900005
n4:zamer
n18:AV0Z40550506
s:issn
0040-4020
s:numberOfPages
7