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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F09%3A00329291%21RIV10-MSM-61388963
rdf:type
n15:Vysledek skos:Concept
dcterms:description
A new capillary electrophoretic method has been developed for chiral analysis of an important anti-AIDS drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine ((R)-PMPA, tenofovir), and six related antiviral acyclic nucleoside phosphonates using beta cyclodextrin (beta CD) as a chiral selector. Complete separations of (R,S)-enantiomers of PMPA with very good resolution (Rs = 1.50 – 3.64) were achieved within a short time (4 – 15 min) in 20 – 50 mM sodium borate or sodium tetraborate BGEs, pH 10.0, at 20 mg/mL concentration of beta CD. A new capillary electrophoretic method has been developed for chiral analysis of an important anti-AIDS drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine ((R)-PMPA, tenofovir), and six related antiviral acyclic nucleoside phosphonates using beta cyclodextrin (beta CD) as a chiral selector. Complete separations of (R,S)-enantiomers of PMPA with very good resolution (Rs = 1.50 – 3.64) were achieved within a short time (4 – 15 min) in 20 – 50 mM sodium borate or sodium tetraborate BGEs, pH 10.0, at 20 mg/mL concentration of beta CD.
dcterms:title
Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector
skos:prefLabel
Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector
skos:notation
RIV/61388963:_____/09:00329291!RIV10-MSM-61388963
n3:aktivita
n10:P n10:Z
n3:aktivity
P(1M0508), P(1QS400550501), P(GA203/06/1044), P(GA203/08/1428), Z(AV0Z40550506)
n3:cisloPeriodika
12
n3:dodaniDat
n17:2010
n3:domaciTvurceVysledku
n6:8514585 n6:9379789 n6:3169138 n6:9587217
n3:druhVysledku
n4:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
306948
n3:idVysledku
RIV/61388963:_____/09:00329291
n3:jazykVysledku
n5:eng
n3:klicovaSlova
antiviral drugs; capillary electrophoresis; enantioseparation
n3:klicoveSlovo
n8:antiviral%20drugs n8:enantioseparation n8:capillary%20electrophoresis
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[DE281D430FFB]
n3:nazevZdroje
Electrophoresis
n3:obor
n12:CB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n13:GA203%2F06%2F1044 n13:GA203%2F08%2F1428 n13:1QS400550501 n13:1M0508
n3:rokUplatneniVysledku
n17:2009
n3:svazekPeriodika
30
n3:tvurceVysledku
Kašička, Václav Šolínová, Veronika Holý, Antonín Sázelová, Petra
n3:wos
000268270400025
n3:zamer
n18:AV0Z40550506
s:issn
0173-0835
s:numberOfPages
10