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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F09%3A00329066%21RIV10-MSM-61388963
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) is the key enzyme in purine metabolism of the malarial parasite Plasmodium falciparum (Pf). Two series of novel branched ANPs derived from 9-[2-(2-phosphonoethoxy)ethyl]purines were synthesized to investigate their inhibition of Pf and human 6-oxopurine phosphoribosyltransferase. Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) is the key enzyme in purine metabolism of the malarial parasite Plasmodium falciparum (Pf). Two series of novel branched ANPs derived from 9-[2-(2-phosphonoethoxy)ethyl]purines were synthesized to investigate their inhibition of Pf and human 6-oxopurine phosphoribosyltransferase.
dcterms:title
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
skos:prefLabel
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
skos:notation
RIV/61388963:_____/09:00329066!RIV10-MSM-61388963
n3:aktivita
n9:Z n9:P
n3:aktivity
P(1M0508), P(1QS400550501), Z(AV0Z40550506)
n3:cisloPeriodika
17
n3:dodaniDat
n12:2010
n3:domaciTvurceVysledku
n4:9345655 n4:9587217 n4:9059261
n3:druhVysledku
n13:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
345099
n3:idVysledku
RIV/61388963:_____/09:00329066
n3:jazykVysledku
n17:eng
n3:klicovaSlova
acyclic nucleoside phosphonates; drug design; phosphoribosyltransferase; enzyme inhibitors; purine salvage pathway
n3:klicoveSlovo
n5:acyclic%20nucleoside%20phosphonates n5:purine%20salvage%20pathway n5:drug%20design n5:enzyme%20inhibitors n5:phosphoribosyltransferase
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[1D1F642605B9]
n3:nazevZdroje
Bioorganic & Medicinal Chemistry
n3:obor
n18:CC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n7:1M0508 n7:1QS400550501
n3:rokUplatneniVysledku
n12:2009
n3:svazekPeriodika
17
n3:tvurceVysledku
Keough, D. T. de Jersey, J. Hocková, Dana Masojídková, Milena Guddat, L. W. Holý, Antonín
n3:wos
000269029100009
n3:zamer
n16:AV0Z40550506
s:issn
0968-0896
s:numberOfPages
15