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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F09%3A00326498%21RIV10-MSM-61388963
rdf:type
n4:Vysledek skos:Concept
dcterms:description
The peptide hydrolysis by GCPII was investigated in detail by carrying out the kinetic analysis of GCPII(E424A) using N-Ac-Asp-Glu as substrate. The crystal structure of GCPII(E424A) in complex with N-Ac-Asp-Glu was determined at 1.70 A resolution. The experimental data were then complemented by the QM/MM calculations which provided detailed information concerning the GCPII reaction mechanism. The peptide hydrolysis by GCPII was investigated in detail by carrying out the kinetic analysis of GCPII(E424A) using N-Ac-Asp-Glu as substrate. The crystal structure of GCPII(E424A) in complex with N-Ac-Asp-Glu was determined at 1.70 A resolution. The experimental data were then complemented by the QM/MM calculations which provided detailed information concerning the GCPII reaction mechanism.
dcterms:title
Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography and computational methods Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography and computational methods
skos:prefLabel
Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography and computational methods Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography and computational methods
skos:notation
RIV/61388963:_____/09:00326498!RIV10-MSM-61388963
n5:aktivita
n15:Z n15:P
n5:aktivity
P(1M0508), P(LC512), Z(AV0Z40550506)
n5:cisloPeriodika
19
n5:dodaniDat
n12:2010
n5:domaciTvurceVysledku
n13:7465157 n13:7120532 n13:7451652 n13:3456668 n13:9367160
n5:druhVysledku
n17:J
n5:duvernostUdaju
n16:S
n5:entitaPredkladatele
n18:predkladatel
n5:idSjednocenehoVysledku
338184
n5:idVysledku
RIV/61388963:_____/09:00326498
n5:jazykVysledku
n11:eng
n5:klicovaSlova
reaction mechanism; QM/MM calculations; glutamate carboxypeptidase II; X-ray crystallography; mutant activity
n5:klicoveSlovo
n9:X-ray%20crystallography n9:glutamate%20carboxypeptidase%20II n9:mutant%20activity n9:QM%2FMM%20calculations n9:reaction%20mechanism
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[1888AAD5DBAC]
n5:nazevZdroje
Biochemistry
n5:obor
n8:CF
n5:pocetDomacichTvurcuVysledku
5
n5:pocetTvurcuVysledku
7
n5:projekt
n6:LC512 n6:1M0508
n5:rokUplatneniVysledku
n12:2009
n5:svazekPeriodika
48
n5:tvurceVysledku
Klusák, Vojtěch Lubkowski, J. Rulíšek, Lubomír Bařinka, C. Konvalinka, Jan Plechanovová, Anna Mlčochová, Petra
n5:wos
000266047400012
n5:zamer
n14:AV0Z40550506
s:issn
0006-2960
s:numberOfPages
13