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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F09%3A00326309%21RIV10-MSM-61388963
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Stability constants of the mixed-ligand complexes formed between Cu(Arm)2+, where Arm = 2,20-bipyridine (Bpy) or 1,10-phenanthroline (Phen), and the monoanion or the dianion of 9-[2-(phosphonomethoxy)ethyl]-2-aminopurine (PME2AP) were determined by potentiometric pH titrations in aqueous solution at 25 ºC and I = 0.1M (NaNO3). Speculatively, the reduced stacking intensity, together with a different hydrogen-bonding pattern, could well lead to a different positioning of the 2-aminopurine moiety (compared to the adenine residue) in the active site cavity of nucleic acid polymerases and thus be responsible for the reduced antiviral activity of PME2AP compared with that of PMEA. Stability constants of the mixed-ligand complexes formed between Cu(Arm)2+, where Arm = 2,20-bipyridine (Bpy) or 1,10-phenanthroline (Phen), and the monoanion or the dianion of 9-[2-(phosphonomethoxy)ethyl]-2-aminopurine (PME2AP) were determined by potentiometric pH titrations in aqueous solution at 25 ºC and I = 0.1M (NaNO3). Speculatively, the reduced stacking intensity, together with a different hydrogen-bonding pattern, could well lead to a different positioning of the 2-aminopurine moiety (compared to the adenine residue) in the active site cavity of nucleic acid polymerases and thus be responsible for the reduced antiviral activity of PME2AP compared with that of PMEA.
dcterms:title
Intramolecular .pi.-.pi. stacking interactions in aqueous solution in mixed-ligand copper (II) complexes formed by heteroaromatic amines and the nucleotide analogue (PME2AP), an isomer of the antivirally active (PMEA) Intramolecular .pi.-.pi. stacking interactions in aqueous solution in mixed-ligand copper (II) complexes formed by heteroaromatic amines and the nucleotide analogue (PME2AP), an isomer of the antivirally active (PMEA)
skos:prefLabel
Intramolecular .pi.-.pi. stacking interactions in aqueous solution in mixed-ligand copper (II) complexes formed by heteroaromatic amines and the nucleotide analogue (PME2AP), an isomer of the antivirally active (PMEA) Intramolecular .pi.-.pi. stacking interactions in aqueous solution in mixed-ligand copper (II) complexes formed by heteroaromatic amines and the nucleotide analogue (PME2AP), an isomer of the antivirally active (PMEA)
skos:notation
RIV/61388963:_____/09:00326309!RIV10-MSM-61388963
n3:aktivita
n5:P n5:Z
n3:aktivity
P(1M0508), Z(AV0Z40550506)
n3:cisloPeriodika
3
n3:dodaniDat
n12:2010
n3:domaciTvurceVysledku
n17:9587217
n3:druhVysledku
n18:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
320213
n3:idVysledku
RIV/61388963:_____/09:00326309
n3:jazykVysledku
n11:eng
n3:klicovaSlova
antiviral activity; intramolecular equilibria; isomeric complexes; phosphonate complexes
n3:klicoveSlovo
n4:phosphonate%20complexes n4:intramolecular%20equilibria n4:isomeric%20complexes n4:antiviral%20activity
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[3B1AEA3F38A2]
n3:nazevZdroje
Inorganica chimica acta
n3:obor
n9:CC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:projekt
n15:1M0508
n3:rokUplatneniVysledku
n12:2009
n3:svazekPeriodika
362
n3:tvurceVysledku
Operschall, B. P. Holý, Antonín Sigel, H. Moreno, V. Fernández-Botello, A.
n3:wos
000262978000020
n3:zamer
n14:AV0Z40550506
s:issn
0020-1693
s:numberOfPages
12