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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F08%3A00310039%21RIV09-AV0-61388963
rdf:type
n17:Vysledek skos:Concept
dcterms:description
The described preparation of 8-aza-7,9-dideazaxanthine from 1,3-dibenzyluracil and TosMIC was improved by using AlCl3 for final debenzylation. Treatment of 6-dibromomethyl- 5-formyluracil with benzyl-, 4-methoxybenzyl-, and 1-adamantylamine gave the corresponding 8-alkyl-8-aza-7,9-dideazaxanthines. N1- and N8-(8-phosphonooctyl)-8-aza-7,9-dideazaxanthines were prepared and found as inhibitors of thymidine phosphorylase (V79 cells, human placenta, Escherichia coli). IC50 values ranged at 3–27 .mu.M. 8-Aza-7,9-dideazaxanthin byl připraven pomocí TosMIC a 1,3-dibenzyluracilu. Postup byl vylepšen užitím AlCl3 pro finální debenzylaci. 8-Alkyl-8-aza-7,9-dideazaxanthiny byly připraveny reakcí 6-dibromomethyl-5-formyluracilu s benzyl-, 4 methoxybenzyl-, a 1 adamantylaminem. Bylo zjištěno že N1- a N8-(8-fosfonooktyl)-8-aza-7,9-dideazaxanthin jsou učinnými inhibitory thymidin fosforylasy (V79 buňky, lidská placenta, Escherichia coli). Hodnoty IC50 3–27 .mu.M. The described preparation of 8-aza-7,9-dideazaxanthine from 1,3-dibenzyluracil and TosMIC was improved by using AlCl3 for final debenzylation. Treatment of 6-dibromomethyl- 5-formyluracil with benzyl-, 4-methoxybenzyl-, and 1-adamantylamine gave the corresponding 8-alkyl-8-aza-7,9-dideazaxanthines. N1- and N8-(8-phosphonooctyl)-8-aza-7,9-dideazaxanthines were prepared and found as inhibitors of thymidine phosphorylase (V79 cells, human placenta, Escherichia coli). IC50 values ranged at 3–27 .mu.M.
dcterms:title
Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine Nukleosidy a nukleotidy obsahující 8-aza-7,9-dideazaxanthin
skos:prefLabel
Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine Nukleosidy a nukleotidy obsahující 8-aza-7,9-dideazaxanthin Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine
skos:notation
RIV/61388963:_____/08:00310039!RIV09-AV0-61388963
n3:aktivita
n14:Z n14:P
n3:aktivity
P(1M0508), P(1QS400550501), Z(AV0Z40550506)
n3:dodaniDat
n10:2009
n3:domaciTvurceVysledku
n8:9587217 n8:8571325 n8:2758849 n8:1570889 n8:8682909
n3:druhVysledku
n4:D
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
383413
n3:idVysledku
RIV/61388963:_____/08:00310039
n3:jazykVysledku
n19:eng
n3:klicovaSlova
8-Aza-7,9-dideaza; xanthine; thymidine phosporylase; debenzylation
n3:klicoveSlovo
n9:debenzylation n9:thymidine%20phosporylase n9:8-Aza-7 n9:9-dideaza n9:xanthine
n3:kontrolniKodProRIV
[4B7E0AA58DCB]
n3:mistoKonaniAkce
Český Krumlov
n3:mistoVydani
Praha
n3:nazevZdroje
Chemistry of Nucleic Acid Components
n3:obor
n18:CC
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n15:1QS400550501 n15:1M0508
n3:rokUplatneniVysledku
n10:2008
n3:tvurceVysledku
Otmar, Miroslav Mařák, David Votruba, Ivan Dračínský, Martin Holý, Antonín
n3:typAkce
n5:EUR
n3:wos
000257885700102
n3:zahajeniAkce
2008-06-08+02:00
n3:zamer
n11:AV0Z40550506
s:numberOfPages
3
n21:hasPublisher
Institute of Organic Chemistry and Biochemistry ASCR
n13:isbn
978-80-86241-29-6