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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F08%3A00309993%21RIV09-AV0-61388963
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Série 6-alkyl-HPMP-5azaC byla připravena s využitím amoniakem katalyzovaného otevírání kruhu chráněného HPMP-5-azaC esteru, následnou kondenzací s orthoestery a deprotekcí esterových skupin. Zavedení mastných acylových skupin do polohy N4 bylo provedeno pomocí přislušných acyl chloridů reakcí s esterem HPMP-5-azaC nebo jeho cyklickou formou. A series of 6-alkyl-HPMP-5azaC was synthesized using ammonia mediated ring-opening reaction of protected HPMP-5-azaC ester followed by condensation reaction with orthoesters and deprotection of ester groups. Introduction of long chain acyl groups to the N4-position was performed using reaction of some acyl chloride (e.g. behenoyl chloride) and appropriate ester of HPMP-5-azaC or its cyclic form. A series of 6-alkyl-HPMP-5azaC was synthesized using ammonia mediated ring-opening reaction of protected HPMP-5-azaC ester followed by condensation reaction with orthoesters and deprotection of ester groups. Introduction of long chain acyl groups to the N4-position was performed using reaction of some acyl chloride (e.g. behenoyl chloride) and appropriate ester of HPMP-5-azaC or its cyclic form.
dcterms:title
New antiviral agent, 1-(S)-[3-hydroxy-(2-phosphonomethoxy)propyl]-5-azacytosin: esters and base modified derivatives Nové virostatikum, 1-(S)-[3-hydroxy-(2-phosphonomethoxy)propyl]-5-azacytosin: estery a modifikované baze New antiviral agent, 1-(S)-[3-hydroxy-(2-phosphonomethoxy)propyl]-5-azacytosin: esters and base modified derivatives
skos:prefLabel
New antiviral agent, 1-(S)-[3-hydroxy-(2-phosphonomethoxy)propyl]-5-azacytosin: esters and base modified derivatives Nové virostatikum, 1-(S)-[3-hydroxy-(2-phosphonomethoxy)propyl]-5-azacytosin: estery a modifikované baze New antiviral agent, 1-(S)-[3-hydroxy-(2-phosphonomethoxy)propyl]-5-azacytosin: esters and base modified derivatives
skos:notation
RIV/61388963:_____/08:00309993!RIV09-AV0-61388963
n4:aktivita
n8:P n8:Z
n4:aktivity
P(1M0508), P(1QS400550501), Z(AV0Z40550506)
n4:dodaniDat
n14:2009
n4:domaciTvurceVysledku
n16:9587217 n16:3058840 n16:5025702
n4:druhVysledku
n19:D
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n11:predkladatel
n4:idSjednocenehoVysledku
382487
n4:idVysledku
RIV/61388963:_____/08:00309993
n4:jazykVysledku
n18:eng
n4:klicovaSlova
HPMP-5-azaC; antiviral; ring-opening
n4:klicoveSlovo
n7:antiviral n7:HPMP-5-azaC n7:ring-opening
n4:kontrolniKodProRIV
[010CB28EE5E8]
n4:mistoKonaniAkce
Český Krumlov
n4:mistoVydani
Praha
n4:nazevZdroje
Chemistry of Nucleic Acid Components
n4:obor
n21:CC
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
7
n4:projekt
n9:1M0508 n9:1QS400550501
n4:rokUplatneniVysledku
n14:2008
n4:tvurceVysledku
Pískala, Alois De Clercq, E. Andrei, G. Holý, Antonín Snoeck, R. Balzarini, J. Krečmerová, Marcela
n4:typAkce
n20:EUR
n4:wos
000257885700031
n4:zahajeniAkce
2008-06-08+02:00
n4:zamer
n17:AV0Z40550506
s:numberOfPages
5
n3:hasPublisher
Institute of Organic Chemistry and Biochemistry ASCR
n13:isbn
978-80-86241-29-6