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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F08%3A00309920%21RIV09-AV0-61388963
rdf:type
n14:Vysledek skos:Concept
dcterms:description
A novel approach to the synthesis of (purin-6-yl)acetates was developed based on Pd-catalysed cross-coupling reactions of 6-chloropurines with the Reformatsky agent. These intermediates were converted into various products by functional group transformations. Amides were prepared by amidation of ester group with amines, 6-(hydroxyethyl)purines by reduction by NaBH4, and beta-substituted 6-ethylpurines by mesylation of 6-(hydroxyethyl)purines and subsequent nucleophilic substitution. Byla vyvinut nový přístup k syntéze (purin-6-yl)acetátů založen na palladiem katalyzovaných cross-coupling reakcích 6-chlorpurinu s Reformackého činidlem. Tyto intermediáty byly přeměněny na další látky transformacemi funkčních skupin. Amidy byly připraveny amidacemi esterové skupiny, 6-(hydroxyethyl)puriny byly redukovány pomocí NaBH4, a beta-substituované 6-ethylpuriny byly připraveny mesylací 6-(hydroxyethyl)purinů a jejich následnou nukleofilní substitucí. A novel approach to the synthesis of (purin-6-yl)acetates was developed based on Pd-catalysed cross-coupling reactions of 6-chloropurines with the Reformatsky agent. These intermediates were converted into various products by functional group transformations. Amides were prepared by amidation of ester group with amines, 6-(hydroxyethyl)purines by reduction by NaBH4, and beta-substituted 6-ethylpurines by mesylation of 6-(hydroxyethyl)purines and subsequent nucleophilic substitution.
dcterms:title
Synthesis of (purin-6-yl)acetates and their transformations Synthesis of (purin-6-yl)acetates and their transformations Syntéza (purin-6-yl)acetátů a jejich transformace
skos:prefLabel
Syntéza (purin-6-yl)acetátů a jejich transformace Synthesis of (purin-6-yl)acetates and their transformations Synthesis of (purin-6-yl)acetates and their transformations
skos:notation
RIV/61388963:_____/08:00309920!RIV09-AV0-61388963
n4:aktivita
n7:P n7:Z
n4:aktivity
P(1M0508), P(1QS400550501), Z(AV0Z40550506)
n4:dodaniDat
n11:2009
n4:domaciTvurceVysledku
n9:6659160 n9:8527806
n4:druhVysledku
n20:D
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n8:predkladatel
n4:idSjednocenehoVysledku
398795
n4:idVysledku
RIV/61388963:_____/08:00309920
n4:jazykVysledku
n17:eng
n4:klicovaSlova
purines; nucleosides; cross-coupling
n4:klicoveSlovo
n5:nucleosides n5:purines n5:cross-coupling
n4:kontrolniKodProRIV
[2F7ECEB16E24]
n4:mistoKonaniAkce
Český Krumlov
n4:mistoVydani
Praha
n4:nazevZdroje
Chemistry of Nucleic Acid Components
n4:obor
n18:CC
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
2
n4:projekt
n10:1M0508 n10:1QS400550501
n4:rokUplatneniVysledku
n11:2008
n4:tvurceVysledku
Hasník, Zbyněk Hocek, Michal
n4:typAkce
n19:EUR
n4:wos
000257885700075
n4:zahajeniAkce
2008-06-08+02:00
n4:zamer
n16:AV0Z40550506
s:numberOfPages
3
n21:hasPublisher
Institute of Organic Chemistry and Biochemistry ASCR
n12:isbn
978-80-86241-29-6