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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F08%3A00306830%21RIV08-AV0-61388963
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Extracellular part of human glutamate carboxypeptidase II was co-crystallized with the phosphapeptide analogs of the enzyme substrates folyl-gamma-glutamate, aspartyl-glutamate, and gamma-glutamyl-glutamate. The determination of the crystal structures allowed us to describe the S1 site of the enzyme in detail for the first time and the corresponding enzyme-ligand interactions, too. Biochemical experiments provided additional information about the influence of the nature of the fragment in the P1 position of the substrate on the hydrolysis rate. Extracellular part of human glutamate carboxypeptidase II was co-crystallized with the phosphapeptide analogs of the enzyme substrates folyl-gamma-glutamate, aspartyl-glutamate, and gamma-glutamyl-glutamate. The determination of the crystal structures allowed us to describe the S1 site of the enzyme in detail for the first time and the corresponding enzyme-ligand interactions, too. Biochemical experiments provided additional information about the influence of the nature of the fragment in the P1 position of the substrate on the hydrolysis rate. Extracelulární část lidské glutamátkarboxypeptidasy II byla vykrystalizována v komplexu s fosfapeptidovými analogy jejích substrátů folyl-gamma-glutamátu, aspartyl-glutamátu a gamma-glutamyl-glutamátu. Rentgenostrukturní analýza umožnila poprvé detailně popsat S1 podmísto enzymu a příslušné interakce s ligandem. Další informace o vlivu druhu fragmentu v P1 pozici substrátu na hydrolýzu poskytla doplňující biochemická měření.
dcterms:title
Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs Strukturální podstata interakcí lidské glutamát karboxypeptidasy II a analogů jejích substrátů Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs
skos:prefLabel
Strukturální podstata interakcí lidské glutamát karboxypeptidasy II a analogů jejích substrátů Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs
skos:notation
RIV/61388963:_____/08:00306830!RIV08-AV0-61388963
n3:strany
1438;1450
n3:aktivita
n6:Z n6:P
n3:aktivity
P(1M0508), Z(AV0Z40550506), Z(MSM 113100001)
n3:cisloPeriodika
5
n3:dodaniDat
n12:2008
n3:domaciTvurceVysledku
n10:8458901 n10:4552008 n10:7120532
n3:druhVysledku
n17:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
397761
n3:idVysledku
RIV/61388963:_____/08:00306830
n3:jazykVysledku
n13:eng
n3:klicovaSlova
prostate-specific membrane antigen; metallopeptidase; folate hydrolase; NAALADase; phosphapeptide
n3:klicoveSlovo
n14:prostate-specific%20membrane%20antigen n14:metallopeptidase n14:phosphapeptide n14:NAALADase n14:folate%20hydrolase
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[D4BC3ACC3345]
n3:nazevZdroje
Journal of Molecular Biology
n3:obor
n16:CE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
11
n3:projekt
n11:1M0508
n3:rokUplatneniVysledku
n12:2008
n3:svazekPeriodika
376
n3:tvurceVysledku
Rovenská, Miroslava Slusher, B. S. Hlouchová, Klára Hin, N. Majer, P. Lubkowski, J. Dauter, M. Konvalinka, Jan Bařinka, C. Ko, Y. S. Tsukamoto, T.
n3:zamer
n18:MSM%20113100001 n18:AV0Z40550506
s:issn
0022-2836
s:numberOfPages
13