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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F08%3A00305989%21RIV08-AV0-61388963
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides were prepared by conjugate additions of nucleophiles to vinyl or ethynylpurines. Cytostatic and antiviral activity of the title compounds is reported. Nové 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- a 6-[2-(dialkylamino)vinyl]purinové nukleosidy byly připraveny konjugovanými adecemi nukleofilů na vinyl nebo ethynylpurinu. Článek presentuje i cytostatickou a antivirovou aktivitu těchto sloučenin. Novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides were prepared by conjugate additions of nucleophiles to vinyl or ethynylpurines. Cytostatic and antiviral activity of the title compounds is reported.
dcterms:title
Syntéza, cytostatická a preotivirová aktivita nových 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- a 6-[2-(dialkylamino)vinyl]purinových nukleosidů Synthesis, cytostatic and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides Synthesis, cytostatic and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides
skos:prefLabel
Synthesis, cytostatic and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides Synthesis, cytostatic and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides Syntéza, cytostatická a preotivirová aktivita nových 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- a 6-[2-(dialkylamino)vinyl]purinových nukleosidů
skos:notation
RIV/61388963:_____/08:00305989!RIV08-AV0-61388963
n4:strany
1400;1424
n4:aktivita
n5:P n5:Z
n4:aktivity
P(1M0508), P(1QS400550501), Z(AV0Z40550506)
n4:cisloPeriodika
3
n4:dodaniDat
n11:2008
n4:domaciTvurceVysledku
n13:3603652 n13:6659160 n13:6959601 n13:8571325
n4:druhVysledku
n18:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
398761
n4:idVysledku
RIV/61388963:_____/08:00305989
n4:jazykVysledku
n7:eng
n4:klicovaSlova
purines; nucleosides; conjugate additions; cytostatic activity
n4:klicoveSlovo
n10:purines n10:conjugate%20additions n10:nucleosides n10:cytostatic%20activity
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[D813E00D99FD]
n4:nazevZdroje
Bioorganic & Medicinal Chemistry
n4:obor
n15:CC
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
7
n4:projekt
n14:1M0508 n14:1QS400550501
n4:rokUplatneniVysledku
n11:2008
n4:svazekPeriodika
16
n4:tvurceVysledku
Pohl, Radek Hocek, Michal Votruba, Ivan Kuchař, Martin Mackman, R. Mabery, E. Shih, I.
n4:zamer
n9:AV0Z40550506
s:issn
0968-0896
s:numberOfPages
25