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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F08%3A00305985%21RIV08-AV0-61388963
rdf:type
n16:Vysledek skos:Concept
dcterms:description
Synthesis of a series of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides was developed based on nucleophilic aubstitutions of 6-(mesyloxymethyl)purines. Title compounds showed cytostatic and antiviral activity. Synthesis of a series of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides was developed based on nucleophilic aubstitutions of 6-(mesyloxymethyl)purines. Title compounds showed cytostatic and antiviral activity. Byla vyvinuta syntéza 6-(N-substituovaných aminomethyl)-, 6-(O- substituovaných hydroxymethyl)- and 6-(S-substituovaných sulfanylmethyl)purin nukleosidů založená na nukleofilních substitucích 6-(mesyloxymethyl)purinů. Látky vykazovaly cytostatickou a protivirovou aktivitu.
dcterms:title
Syntéza, cytostatická a protivirová aktivita 6-(N-substituovaných aminomethyl)-, 6-(O- substituovaných hydroxymethyl)- and 6-(S-substituovaných sulfanylmethyl)purin nukleosidů Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides
skos:prefLabel
Syntéza, cytostatická a protivirová aktivita 6-(N-substituovaných aminomethyl)-, 6-(O- substituovaných hydroxymethyl)- and 6-(S-substituovaných sulfanylmethyl)purin nukleosidů Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides
skos:notation
RIV/61388963:_____/08:00305985!RIV08-AV0-61388963
n3:strany
2329;2366
n3:aktivita
n10:Z n10:P
n3:aktivity
P(1M0508), P(1QS400550501), Z(AV0Z40550506)
n3:cisloPeriodika
5
n3:dodaniDat
n5:2008
n3:domaciTvurceVysledku
n4:3603652 n4:6659160 n4:1342851 n4:8571325
n3:druhVysledku
n14:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
398760
n3:idVysledku
RIV/61388963:_____/08:00305985
n3:jazykVysledku
n18:eng
n3:klicovaSlova
purines; nucleosides; cytostatics; antivirals
n3:klicoveSlovo
n13:antivirals n13:cytostatics n13:purines n13:nucleosides
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[7639DE28E623]
n3:nazevZdroje
Bioorganic & Medicinal Chemistry
n3:obor
n11:CC
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:projekt
n8:1M0508 n8:1QS400550501
n3:rokUplatneniVysledku
n5:2008
n3:svazekPeriodika
16
n3:tvurceVysledku
Šilhár, Peter Mabery, E. Shih, I. Mackman, R. Pohl, Radek Hocek, Michal Votruba, Ivan
n3:zamer
n15:AV0Z40550506
s:issn
0968-0896
s:numberOfPages
38