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Statements

Subject Item
n2:RIV%2F61388963%3A_____%2F06%3A00043419%21RIV07-AV0-61388963
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Aspartátové proteasy sekretované C. albicans (Sap2p), C. tropicalis (Sapt1p) a C. parapsilosis (Sapp1p) byly purifikovány a testovány se sérií různě modifikovaných peptidomimetických inhibitorů. Vybrané látky inhibovaly proteasy v nanomolárních koncentracích. Srovnání primárních struktur a homologní modelování struktury (Sapp1p) se známými strukturami Sapt1p a komplexu inhibitoru se Sap2p umožnily identifikovat strukturní prvky odpovědné za rozdílnou inhibici jednotlivých proteas. Aspartic proteases secreted by C. albicans (Sap2p), C. tropicalis (Sapt1p), and C. parapsilosis (Sapp1p) were purified and tested for inhibition with a series of peptidomimetic inhibitors with different modifications. Selected compounds inhibited proteases in nanomolar concentration. The sequence alignment of Sap2p, Sapt1p, and Sapp1p and homology modeling of Sapp1p with the crystal structure of Sapt1p and the complex of Sap2p with a peptidomimetic inhibitor identified structural differences, which lead to different susceptibility of individual proteases to inhibition. Aspartic proteases secreted by C. albicans (Sap2p), C. tropicalis (Sapt1p), and C. parapsilosis (Sapp1p) were purified and tested for inhibition with a series of peptidomimetic inhibitors with different modifications. Selected compounds inhibited proteases in nanomolar concentration. The sequence alignment of Sap2p, Sapt1p, and Sapp1p and homology modeling of Sapp1p with the crystal structure of Sapt1p and the complex of Sap2p with a peptidomimetic inhibitor identified structural differences, which lead to different susceptibility of individual proteases to inhibition.
dcterms:title
Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling Srovnání specifit a struktur sekretovaných aspartátových proteas z Candidy parapsilosis, Candidy albicans a Candidy tropicalis pomocí peptidomimetických inhibitorů a homologního modelování Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling
skos:prefLabel
Srovnání specifit a struktur sekretovaných aspartátových proteas z Candidy parapsilosis, Candidy albicans a Candidy tropicalis pomocí peptidomimetických inhibitorů a homologního modelování Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling
skos:notation
RIV/61388963:_____/06:00043419!RIV07-AV0-61388963
n3:strany
1247;1254
n3:aktivita
n15:P n15:Z
n3:aktivity
P(GA303/04/0432), P(LC531), Z(AV0Z40550506)
n3:cisloPeriodika
9
n3:dodaniDat
n14:2007
n3:domaciTvurceVysledku
n12:2264102 n12:9427333 n12:9255230 n12:6949924 n12:1118722
n3:druhVysledku
n11:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
502016
n3:idVysledku
RIV/61388963:_____/06:00043419
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Candida albicans; Candida parapsilosis; Candida inhibitors; secreted aspartic protease
n3:klicoveSlovo
n6:Candida%20albicans n6:Candida%20inhibitors n6:Candida%20parapsilosis n6:secreted%20aspartic%20protease
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[2C6C8438B73F]
n3:nazevZdroje
Biological Chemistry
n3:obor
n5:CE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
7
n3:projekt
n10:GA303%2F04%2F0432 n10:LC531
n3:rokUplatneniVysledku
n14:2006
n3:svazekPeriodika
387
n3:tvurceVysledku
Majer, F. Hradilek, Martin Hrušková, Olga Pavlíčková, Libuše Pichová, Iva Majer, P. Dolejší, Elena
n3:zamer
n7:AV0Z40550506
s:issn
1431-6730
s:numberOfPages
8