This HTML5 document contains 48 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n18http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n8http://linked.opendata.cz/resource/domain/vavai/projekt/
n17http://linked.opendata.cz/resource/domain/vavai/subjekt/
n4http://linked.opendata.cz/ontology/domain/vavai/
n19http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F61388955%3A_____%2F13%3A00393961%21RIV14-GA0-61388955/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n5http://linked.opendata.cz/ontology/domain/vavai/riv/
n15http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n7http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n6http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n14http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n13http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F61388955%3A_____%2F13%3A00393961%21RIV14-GA0-61388955
rdf:type
n4:Vysledek skos:Concept
dcterms:description
New linear cationic surfactants – 2-(alkyldimethylammonio)ethylgluconamide bromides, denoted as CnGAB, n = 10, 12, 14 and 16 – were synthesized from natural resources and characterized with respect to their potential as gene-delivery agents in gene therapy applications. Interactions with plasmid DNA and with model membranes were studied both experimentally and theoretically. The compounds with n = 12, 14 and 16 show exponentially increasing ability to fully condense DNA. C16GAB condenses DNA at 1:1 surfactant to nucleotide molar ratio. Furthermore, CnGABs interact with model membrane, slightly lowering the temperature of the main phase transition Tm of the DPPC bilayer. C10GAB is found to interact only at the membrane surface. C16GAB reduces Tm less than C12GAB and C14GAB, and forms domains in the bilayer at the surfactant/DPPC molar ratio of 0.1 and higher. The results suggest that C16GAB can be a promising candidate for building gene-delivery carrier systems. New linear cationic surfactants – 2-(alkyldimethylammonio)ethylgluconamide bromides, denoted as CnGAB, n = 10, 12, 14 and 16 – were synthesized from natural resources and characterized with respect to their potential as gene-delivery agents in gene therapy applications. Interactions with plasmid DNA and with model membranes were studied both experimentally and theoretically. The compounds with n = 12, 14 and 16 show exponentially increasing ability to fully condense DNA. C16GAB condenses DNA at 1:1 surfactant to nucleotide molar ratio. Furthermore, CnGABs interact with model membrane, slightly lowering the temperature of the main phase transition Tm of the DPPC bilayer. C10GAB is found to interact only at the membrane surface. C16GAB reduces Tm less than C12GAB and C14GAB, and forms domains in the bilayer at the surfactant/DPPC molar ratio of 0.1 and higher. The results suggest that C16GAB can be a promising candidate for building gene-delivery carrier systems.
dcterms:title
New gluconamide-type cationic surfactants: Interactions with DNA and lipid membranes New gluconamide-type cationic surfactants: Interactions with DNA and lipid membranes
skos:prefLabel
New gluconamide-type cationic surfactants: Interactions with DNA and lipid membranes New gluconamide-type cationic surfactants: Interactions with DNA and lipid membranes
skos:notation
RIV/61388955:_____/13:00393961!RIV14-GA0-61388955
n4:predkladatel
n17:ico%3A61388955
n5:aktivita
n12:P n12:I
n5:aktivity
I, P(GBP208/12/G016)
n5:cisloPeriodika
OCT-NOV
n5:dodaniDat
n13:2014
n5:domaciTvurceVysledku
Kral, Teresa n18:3982181
n5:druhVysledku
n11:J
n5:duvernostUdaju
n6:S
n5:entitaPredkladatele
n19:predkladatel
n5:idSjednocenehoVysledku
91584
n5:idVysledku
RIV/61388955:_____/13:00393961
n5:jazykVysledku
n14:eng
n5:klicovaSlova
Glucose-derived surfactant; Soft surfactant; Cationic surfactant
n5:klicoveSlovo
n7:Glucose-derived%20surfactant n7:Cationic%20surfactant n7:Soft%20surfactant
n5:kodStatuVydavatele
NL - Nizozemsko
n5:kontrolniKodProRIV
[EA51387F7D4B]
n5:nazevZdroje
Biophysical Chemistry
n5:obor
n16:CF
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
8
n5:projekt
n8:GBP208%2F12%2FG016
n5:rokUplatneniVysledku
n13:2013
n5:svazekPeriodika
180-181
n5:tvurceVysledku
Kral, Teresa Misiak, P. Wilk, K. A. Pruchnik, H. Rózycka-Roszak, B. Frackowiak, R. Hof, Martin Wozniak, E.
n5:wos
000324898700006
s:issn
0301-4622
s:numberOfPages
11
n15:doi
10.1016/j.bpc.2013.06.010