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Statements

Subject Item
n2:RIV%2F61388955%3A_____%2F11%3A00360337%21RIV12-AV0-61388955
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Poloxamers are triblock copolymers made of poly(ethylene glycol)-(poly(propylene glycol))-poly(ethylene glycol). They have been shown to enhance gene transfer in the muscle, and co-administration of polymers and DNA appeared to be crucial to obtain this effect. It is questionable then if some interaction occurs between polymers and DNA. Polymer interaction with membranes represents a second crucial point due to the central hydrophobic part of the triblock copolymers. Besides, the question of the polymer spanning or adsorbing to the surface has not been solved by now. We addressed these issues by means of sensitive techniques that allowed working in diluted conditions and gaining in comprehension of gene transfection. By means of simultaneous time-correlated single-photon counting and fluorescence correlation spectroscopy, we have shown that the diffusion time of a single DNA molecule and PicoGreen lifetime was not altered in the presence of the triblock copolymer L64. Poloxamers are triblock copolymers made of poly(ethylene glycol)-(poly(propylene glycol))-poly(ethylene glycol). They have been shown to enhance gene transfer in the muscle, and co-administration of polymers and DNA appeared to be crucial to obtain this effect. It is questionable then if some interaction occurs between polymers and DNA. Polymer interaction with membranes represents a second crucial point due to the central hydrophobic part of the triblock copolymers. Besides, the question of the polymer spanning or adsorbing to the surface has not been solved by now. We addressed these issues by means of sensitive techniques that allowed working in diluted conditions and gaining in comprehension of gene transfection. By means of simultaneous time-correlated single-photon counting and fluorescence correlation spectroscopy, we have shown that the diffusion time of a single DNA molecule and PicoGreen lifetime was not altered in the presence of the triblock copolymer L64.
dcterms:title
A comprehensive study in triblock copolymer membrane interaction A comprehensive study in triblock copolymer membrane interaction
skos:prefLabel
A comprehensive study in triblock copolymer membrane interaction A comprehensive study in triblock copolymer membrane interaction
skos:notation
RIV/61388955:_____/11:00360337!RIV12-AV0-61388955
n14:predkladatel
n15:ico%3A61388955
n3:aktivita
n17:P n17:Z
n3:aktivity
P(IAA400400621), P(LC06063), Z(AV0Z40400503)
n3:cisloPeriodika
1
n3:dodaniDat
n4:2012
n3:domaciTvurceVysledku
Kral, Teresa n11:3982181
n3:druhVysledku
n18:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
183715
n3:idVysledku
RIV/61388955:_____/11:00360337
n3:jazykVysledku
n9:eng
n3:klicovaSlova
poloxamer; pluronic; liposomes
n3:klicoveSlovo
n5:liposomes n5:poloxamer n5:pluronic
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[2B63247246A7]
n3:nazevZdroje
Journal of Controlled Release
n3:obor
n6:CF
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:projekt
n13:LC06063 n13:IAA400400621
n3:rokUplatneniVysledku
n4:2011
n3:svazekPeriodika
151
n3:tvurceVysledku
Morellet, N. Mignet, N. Scherman, D. Bureau, M.-F. Kral, Teresa Hof, Martin Pembouong, G.
n3:wos
000291240900009
n3:zamer
n12:AV0Z40400503
s:issn
0168-3659
s:numberOfPages
8
n16:doi
10.1016/j.jconrel.2011.01.007